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ProteomicsSleeve-Gastrectomy results in improved metabolism and a massive stress response of the liver proteome in a mouse model of nonalcoholic steatohepatitis
Introduction: Bariatric surgery has been shown to improve the histopathological findings in patients with obesity and non-alcoholic steatohepatitis, but there are also reports about non-responder or progressive disease after bariatric interventions. Therefore, it is of utmost importance to understa...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-21 | PXD044185 | Pride
Liver Nashh Lc-ms Mouse 
ProteomicsLiver epithelial cell-specific loss of mTOR aggravates tumor development in a murine model of nonalcoholic steatohepatitis related hepatocellular carcinoma
Due to the global obesity epidemic the incidences of nonalcoholic steatohepatitis (NASH) and NASH-related hepatocellular carcinoma (HCC) are on the rise. Non-invasive treatment options for HCC are scarce and innovative therapy regimes are urgently needed. The mechanistic target of rapamycin (mTOR) i...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-15 | PXD039944 | Pride
Lc-msms Liver Hcc Mouse Proteome Label free 
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