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TranscriptomicsEpigenetic memory of the first cell fate decision prevents complete ES cell reprogramming into trophoblast
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2014-11-24 | E-GEOD-62150 | biostudies-arrayexpress
GenomicsDNA Methylation Profiles Define Stem Cell Identity and Reveal a Tight Embryonic-Extraembryonic Lineage Boundary
Embryonic (ES) and epiblast (EpiSC) stem cells are pluripotent but committed to an embryonic lineage fate. Conversely, trophoblast (TS) a nd extraembryonic endoderm (XEN) stem cells contribute predominantly to tissues of the placenta and yolk sac, respectively. Here we show that each of these four s...
ORGANISM(S): Mus musculus 
2013-07-03 | E-MTAB-1754 | biostudies-arrayexpress
GenomicsSingle-Cell Whole-Genome Bisulfite Sequencing for Analysis of Epigenetic Heterogeneity
We report a single-cell whole-genome bisulfite sequencing method (scBS-Seq) capable of accurately measuring DNA methylation at up to 36% of CpGs. We observed that ESCs grown in serum/LIF or 2i/LIF both display epigenetic heterogeneity, with M-bM-^@M-^\2i-likeM-bM-^@M-^] cells present in serum cultur...
ORGANISM(S): Mus musculus 
2014-07-18 | E-GEOD-56879 | biostudies-arrayexpress
TranscriptomicsRNA-seq of the ventral compartment of the middle gluteal muscle in untrained at resting Thoroughbred horses, comparing the age of two years old and three years old
The development stage between two and three years old of age is very important for Thoroughbred horses, as the Thoroughbred horses would experience high intense exercise and training. This study was designed to investigate the transcriptional changes in the skeletal muscle of untrained Thoroughbred ...
ORGANISM(S): Equus caballus 
2026-05-20 | E-MTAB-15170 | biostudies-arrayexpress
GenomicsGenome-wide bisulfite sequencing in zygotes identifies demethylation targets and maps the contribution of TET3 oxidation
Fertilization triggers a global erasure of 5-methylcytosine from paternal DNA as part of extensive epigenetic reprogramming during the transition from gametic specialization to totipotency. This active removal has been shown to involve oxidation by TET3, but the targeting of this pathway and the wid...
ORGANISM(S): Mus musculus 
2014-12-22 | E-GEOD-63417 | biostudies-arrayexpress
TranscriptomicsHuR- dependent regulation of mRNA splicing is essential for the B cell antibody response [Ribo-Seq]
Post-transcriptional regulation of mRNA by the RNA binding protein HuR is required in B cells for the germinal centre reaction and for the production of class-switched antibodies in response to T-independent antigens. Transcriptome-wide examination of RNA isoforms, abundance and translation in HuR-d...
ORGANISM(S): Mus musculus 
2015-02-13 | E-GEOD-62134 | biostudies-arrayexpress
GenomicsAllele-specific binding of ZFP57 in the regulation of imprinted and mono-allelic expression
Selective maintenance of genomic methylation imprints during pre-implantation development is required for parental origin-specific expression of imprinted genes. The Kruppel-like zinc finger protein ZFP57 acts as a factor necessary for maintaining the DNA methylation memory at multiple imprinting co...
ORGANISM(S): Mus musculus 
2015-05-08 | E-GEOD-55382 | biostudies-arrayexpress
UnknownRecombination Suppression Drives Expansion of the Drosophila Dot Chromosome.
Not available
S-EPMC12728734 | biostudies-literature
UnknownAnticholinergic and Sedative Medications Are Associated With Neurocognitive Performance of Well Treated People With Human Immunodeficiency Virus.
Not available
S-EPMC9487636 | biostudies-literature
UnknownHow helpful are the European AIDS Clinical Society cognitive screening questions in predicting cognitive impairment in an aging, well-treated HIV-positive population?
Not available
S-EPMC7216878 | biostudies-literature
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