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TranscriptomicsGene-environment interaction in yeast gene expression
This study is a quantitative trait linkage mapping study targeted at gene-environment interaction. A family of yeast derived from BY4716 and RM11-1a was grown in two carbon sources (glucose and ethanol) and expression profiled. The analysis revealed how the influence of genetic factors changes in di...
ORGANISM(S): Saccharomyces cerevisiae 
2008-04-15 | E-GEOD-9376 | biostudies-arrayexpress
ProteomicsGenome-wide base editor screen identifies regulators of protein abundance in yeast
Proteins are key molecular players in a cell, and their abundance is extensively regulated not just at the level of gene expression but also post-transcriptionally. Here, we describe a genetic screen in yeast that enables systematic characterization of how protein abundance regulation is encoded in ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-11-07 | PXD029363 | Pride
Lc-msms Yeast 
TranscriptomicsIntegrating Large-Scale Functional Genomic Data to Dissect the Complexity of Yeast Regulatory Networks
A major goal of biology is the construction of networks that predict complex system behavior. We combine multiple types of molecular data, including genotypic, expression, transcription factor binding site (TFBS), and protein-protein interaction (PPI) data previously generated from a number of yeas...
ORGANISM(S): Saccharomyces cerevisiae 
2008-06-15 | E-GEOD-11111 | biostudies-arrayexpress
TranscriptomicsA variant in the neuropeptide receptor npr-1 is a major determinant of Caenorhabditis elegans growth and physiology
The mechanistic basis for how genetic variants cause differences in phenotypic traits is often elusive. We identified a quantitative trait locus in C. elegans that affects three seemingly unrelated phenotypic traits: lifetime fecundity, adult body size, and susceptibility to the human pathogen Staph...
ORGANISM(S): Caenorhabditis elegans 
2013-07-30 | E-GEOD-49307 | biostudies-arrayexpress
TranscriptomicsTranscription profiling and genotyping, detection of allele specific gene expression of Saccharomyces BY, isogenic to S288C, and RM, a wild vineyard strain
By hybridizing mRNA to oligonucleotide arrays and searching for probes that are outliers in their probe set, we identify and genotype polymorhisms in two strains of yeast (BY, isogenic to S288C, and RM, a wild vineyard strain) and segregants from a cross between the two strains. We then use this mR...
ORGANISM(S): Saccharomyces cerevisiae 
2008-06-11 | E-GEOD-1975 | biostudies-arrayexpress
TranscriptomicsRibosomal footprinting and RNASeq in two strains of yeast and their diploid hybrid
Heritable differences in gene expression between individuals are an important source of phenotypic variation. The question of how closely the effects of genetic variation on protein levels mirror those on mRNA levels remains open. Here, we addressed this question by using ribosomal footprinting to e...
ORGANISM(S): Saccharomyces cerevisiae 
2014-03-31 | E-GEOD-55400 | biostudies-arrayexpress
Transcriptomicsrat_brain_mRNASeq
mRNA Sequencing was done in whole brain hemispheres of the 75 most tame and 75 most aggressive rats of an F2 intercross of rat lines selected for tame and aggressive behavior towards humans. The brain gene expression levels are associated with 1728 genetic markers across the genome to identify expr...
ORGANISM(S): Rattus norvegicus 
2014-08-27 | E-MTAB-2544 | biostudies-arrayexpress
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