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ProteomicsHigh temporal resolution proteome and phosphoproteome profiling of stem cell-derived hepatocyte development
Primary human hepatocytes are widely used to evaluate liver toxicity of drugs, but they are scarce and demanding to culture. Stem cell-derived hepatocytes are increasingly discussed as alternatives. To obtain a better appreciation of the molecular processes during the differentiation of induced plur...
ORGANISM(S): Homo sapiens (Human) 
2022-04-01 | PXD027439 | Pride
Hepatocyte differentiation Quantitative mass spectrometry Phosphoproteomics 2d versus 3d differentiation Stem cell-derived organoids 
ProteomicsMutations and variants of ONECUT1 in diabetes
Genes involved in distinct diabetes types suggest shared disease mechanisms. We show that rare ONECUT1 coding variants cause monogenic recessive diabetes (neonatal or very early-onset, syndromic) in two unrelated patients, and monogenic dominant diabetes (early adult-onset) in heterozygous relatives...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD018887 | Pride
Differentiation Stem cells Onecut1 Proteomics 
UnknownStrong and early immune responses against SARS-CoV-2 in mice and rhesus macaques after BNT162b3 vaccination.
Not available
S-EPMC12804745 | biostudies-literature
ProteomicsMass spectrometry-based draft of the mouse proteome
Quantitative draft map of the proteomes of 41 healthy tissues of the animal model Mus musculus and a panel of 66 murine pancreatic ductal adenocarcinoma cell lines and. Our in-depth analysis provides evidence for proteins encoded by >16,000 genes (~76% of the total annotated protein-coding genes), w...
ORGANISM(S): Mus musculus (Mouse) 
2022-04-01 | PXD030983 | Pride
Mouse Phosphoproteome Mus musculus Drug sensitivity Proteome Pdac Pancreatic cancer Radiation sensitivity 
UnknownMass spectrometry-based draft of the mouse proteome.
Not available
S-EPMC7613032 | biostudies-literature
ProteomicsMass spectrometry-based draft of the mouse proteome
Quantitative draft map of the proteomes of 41 healthy tissues of the animal model Mus musculus and a panel of 66 murine pancreatic ductal adenocarcinoma cell lines and. Our in-depth analysis provides evidence for proteins encoded by >16,000 genes (~76% of the total annotated protein-coding genes), w...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-07-09 | MSV000089856 | MassIVE
UnknownDIGitoxin to Improve ouTcomes in patients with advanced chronic Heart Failure (DIGIT-HF): Baseline characteristics compared to recent randomized controlled heart failure trials.
Not available
S-EPMC12370576 | biostudies-literature
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