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TranscriptomicsmicroRNA Targetome Analysis of Latently KSHV-infected Primary Effusion Lymphoma Cell lines Using PAR-CLIP [Illumina]
Primary effusion lymphoma (PEL) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV) and frequently also harbors Epstein-Barr virus (EBV). The expression of KSHV- and, often, EBV-encoded microRNAs (miRNAs) in PELs suggests a role for these miRNAs in viral latency and lymphomagenesis. Here we ...
ORGANISM(S): Homo sapiens 
2011-11-16 | E-GEOD-32109 | biostudies-arrayexpress
TranscriptomicsvGPCR and lytic KSHV time course in TIME cells
TIME cells either expressing KSHV-RTA or KSHV-vGPCR alone, or TIME cells infected with KSHV and lytically reactivated with RTA for 6, 12, or 20 hours. Keywords = KSHV Keywords = host shutoff Keywords = vGPCR
ORGANISM(S): Homo sapiens 
2010-06-09 | E-GEOD-1406 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of lymphatic endothelial cells infected with Kaposi's sacoma associated herpes virus
This SuperSeries is composed of the following subset Series: GSE16353: The profile of cellular and KSHV microRNAs in AIDS_KS biopsies (and normal skin control biopsies) GSE16354: Infection of Lymphatic and Blood Vessel Endothelial Cells (LEC and BEC) with KSHV GSE16355: Lymphatic endothelial cells (...
ORGANISM(S): Homo sapiens 
2009-09-30 | E-GEOD-16357 | biostudies-arrayexpress
TranscriptomicsAgo HITS-CLIP in KSHV-infected primary effusion lymphoma (PEL) cell lines BCBL-1 and BC-3
We performed Ago HITS-CLIP to identify targets of viral and human miRNAs in latently KSHV-infected PEL cells Ago HITS-CLIP was performed in two latently infected PEL cell lines, BCBL-1 and BC-3; Argonaute-immunoprecipitation of UV cross-linked Ago-miRNA-mRNA complexes, followed by RNA isolation, lib...
ORGANISM(S): Homo sapiens 
2012-10-05 | E-GEOD-41357 | biostudies-arrayexpress
GenomicsGenome-wide ChIP sequence analysis of KSHV-infected primary effusion lymphoma (PEL) cell line BCBL-1 and human umbilical vein endothelial TIVE-LTC cells.
Kaposi’s sarcoma-associated herpesvirus (KSHV) is a g-herpesvirus which persists as circular extrachromasomal DNA in the nucleus during latent infection. During latency a limited number of viral proteins are expressed, including LANA (latency-associated nuclear antigen). LANA is a multi-functional ...
ORGANISM(S): Homo sapiens 
2014-10-27 | E-GEOD-52421 | biostudies-arrayexpress
ProteomicsQuantitative proteomics analysis of lytic KSHV infection in human endothelial cells reveals novel targets of viral immune modulation
Kaposi’s Sarcoma associated herpesvirus (KSHV) is an oncogenic human virus and leading cause of mortality in HIV infection. Reactivation of KSHV from latent to lytic stage infection initiates a cascade of viral gene expression, and here we show how these changes remodel the host cell proteome to ena...
ORGANISM(S): Homo sapiens (Human) Human gammaherpesvirus 8 
2021-08-23 | PXD021387 | Pride
Kshv 
TranscriptomicsKnockdown of KSHV viral interferon-regulatory factor 3 (vIRF-3) in primary effusion lymphoma (PEL) cells by RNA-Interference
KaposiM-bM-^@M-^Ys sarcoma-associated hepesvirus (KSHV) encodes four genes with homology to human interferon regulatory factors (IRFs). One of these IRFs, the viral interferon regulatory factor 3 (vIRF-3) is expressed in latently infected PEL cells and required for their continuous proliferation. Mo...
ORGANISM(S): Homo sapiens 
2011-01-19 | E-GEOD-26661 | biostudies-arrayexpress
GenomicsThe Open Chromatin Landscape of Kaposi's Sarcoma-Associated Herpesvirus
KaposiM-bM-^@M-^Ys sarcoma-associated herpesvirus (KSHV) is an oncogenic gammaherpesvirus which establishes latent infection in endothelial and B cells, as well as in primary effusion lymphoma (PEL). During latency, the viral genome exists as a circular DNA minichromosome (episome) and is packaged i...
ORGANISM(S): Human herpesvirus 8 
2013-09-05 | E-GEOD-50581 | biostudies-arrayexpress
TranscriptomicsMock or latently infected KSHV cells (BCBL, SLK and HFF)
[original title] Mock or latently infected KSHV cells (BCBL, SLK and HFF) vs common reference (mixture of RNA from both infected and uninfected cells). Expression profiling of latently infected cells using a custom tiling microarray. SLK and HFF cells were infected and selected for rKSHV.219. Mock ...
ORGANISM(S): Homo sapiens 
2010-06-05 | E-GEOD-20443 | biostudies-arrayexpress
ProteomicsQuantitative proteomics analysis of lytic KSHV infection in human endothelial cells reveals novel targets of viral immune modulation
Kaposi’s Sarcoma associated herpesvirus (KSHV) is an oncogenic human virus and leading cause of mortality in HIV infection. Reactivation of KSHV from latent to lytic stage infection initiates a cascade of viral gene expression, and here we show how these changes remodel the host cell proteome to ena...
ORGANISM(S): Homo sapiens (Human) Human herpesvirus 8 strain rKSHV.219 
2022-05-26 | PXD017365 | Pride
Proteomics Kshv Immune modulation 
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