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TranscriptomicsRNA-seq of mouse ileum to investigate the role of IL-17 receptor signaling in Paneth cells in their biology and intestinal physiology
IL-17 receptor plays a major role in the antibacterial defense and regulation of host-microbiota interaction. However its impact on Paneth cells, cell-type specific for production of antibacterial peptides, is still not clear. Here, we used genetic depletion of IL-17 receptor specific for Paneth cel...
ORGANISM(S): Mus musculus 
2022-01-01 | E-MTAB-10038 | biostudies-arrayexpress
TranscriptomicsSingle cell expression analysis of Defa6+ cells possessing either wild-type Tcf4 or homozygous loss of the Tcf4 protein isolated from mouse small intestinal epithelium
The T-cell factor 4 (Tcf4) protein (encoded by the Tcf7l2 gene) is a nuclear transcription regulator, which plays a key role in maintaining intestinal homeostasis, stem cell self-renewal and epithelial cell differentiation. Tcf4 has been identified as a crucial regulator of Paneth cell function in s...
ORGANISM(S): Mus musculus 
2026-06-29 | E-MTAB-14489 | biostudies-arrayexpress
TranscriptomicsExpression profiling of Defa6+ cells isolated from Apc-deficient colon tumor using single-cell RNA-Seq
Aberrant activation of the canonical Wnt pathway underlines the development and growth of intestinal tumors. The Apc-min (multiple intestinal neoplasia) mouse strain carries a single nucleotide mutation in one allele of the Apc tumor suppressor gene. Random deactivation of the second allele occurs d...
ORGANISM(S): Mus musculus 
2025-04-01 | E-MTAB-13752 | biostudies-arrayexpress
TranscriptomicsSingle cell RNA-Seq expression profiling of RFP-positive cells isolated from Ki67-RFP/Tcf7l2/Villin-CreERT2 mouse small intestinal epithelium 7 days after tamoxifen administration
The T-cell factor 4 (Tcf4) protein (encoded by the Tcf7l2 gene) is a nuclear transcription regulator, which plays a key role in maintaining intestinal homeostasis, stem cell self-renewal and epithelial cell differentiation. Tcf4 has been identified as a key regulator of Paneth cell function in small...
ORGANISM(S): Mus musculus 
2026-06-29 | E-MTAB-13731 | biostudies-arrayexpress
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