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ProteomicsRepression of Human Papillomavirus Oncogene Expression under Hypoxia is Mediated by PI3K/mTORC2/AKT Signaling
Cornerstones of the regulatory phenomena observed in hypoxic HPV-positive cancer cells are: (i) hypoxia blocks E6/E7, an effect that can be counteracted by (ii) AKT inhibition and by (iii) high glucose supply. To gain further insights into the underlying regulatory circuits, mass spectrometry-based ...
ORGANISM(S): Homo sapiens (Human) 
2019-02-18 | PXD011095 | Pride
Human Hpv Tmt Quantitative proteomics Hypoxia 
ProteomicsTemporal multi-omics identifies LRG1 as vascular instructor of early metastatic colonization.
Metastasis is the primary cause of cancer-related mortality and the mechanistically least well understood step of the tumor progression cascade. Employing surgical preclinical metastasis models, we show here that small primary tumors reprogram the body’s vascular endothelium to alter systemic homeos...
ORGANISM(S): Mus musculus (Mouse) 
2022-05-16 | PXD013978 | Pride
And vascular niche Lrg1 Endothelial cells Cancer Metastasis 
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