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ProteomicsPrion MRM assay development and clinical study
Therapies currently in preclinical development for prion disease seek to lower prion protein (PrP) expression in the brain. Trials of such therapies are likely to rely on quantification of PrP in cerebrospinal fluid (CSF) as a pharmacodynamic biomarker and possibly as a trial endpoint. Studies using...
ORGANISM(S): Homo Sapiens Rattus Norvegicus Mus Musculus Macaca Fascicularis 
2019-11-19 | PXD014781 | panorama
ProteomicsPrP concentration in the central nervous system: regional variability, genotypic effects, and pharmacodynamic impact
Prion protein (PrP) concentration controls the kinetics of prion replication and is a genetically and pharmacologically validated therapeutic target for prion disease. In order to evaluate PrP concentration as a pharmacodynamic biomarker and assess its contribution to known prion disease risk factor...
ORGANISM(S): Homo Sapiens Rattus Norvegicus 
2022-02-28 | PXD031432 | panorama
ProteomicsRefined preparation and use of K-GG antibody enables routine quantification of ubiquitination sites
Not available
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2015-04-03 | MSV000079097 | MassIVE
ProteomicsSensitive Biomarker Discovery in Plasma Yields Novel Candidates for Early Myocardial Injury
Not available
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2015-02-09 | MSV000079033 | MassIVE
OtherMultiplexed, Quantitative Workflow for Sensitive Biomarker Discovery in Plasma Yields Novel Candidates for Early Myocardial Injury.
Data from Massive, ID: MSV000078918. Experiment: Discovery_inPatient_IgY14_Supermix_depletion, PMI_Patient1, file: G20121012_PMI_P24_SMdepl_iTRAQ_basicRP_fr23.mzml. Published as part of Mol Cell Proteomics. 2015 Feb 27 . From the Abstract: {{i}} We have developed a novel plasma protein analysis pla...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM11210037151 | GPMDB
ProteomicsIgY14_Supermix_depletion_PMI_P4_iTRAQ
IgY14/Supermix depletion, patient 4, iTRAQ
ORGANISM(S): Homo Sapiens (human) 
2015-12-31 | PAe005319 | PeptideAtlas
ProteomicsIgY14_depletion_PMI_P1_iTRAQ
IgY14 only depletion, patient 1, iTRAQ
ORGANISM(S): Homo Sapiens (human) 
2015-12-31 | PAe005318 | PeptideAtlas
ProteomicsIgY14_Supermix_depletion_PMI_P2_iTRAQ
IgY14/Supermix depletion, patient 2, iTRAQ
ORGANISM(S): Homo Sapiens (human) 
2015-12-31 | PAe005317 | PeptideAtlas
ProteomicsiTRAQ_TMT_Comparison_TMT6
IgY14/Supermix depletion, TMT6
ORGANISM(S): Homo Sapiens (human) 
2015-12-31 | PAe005316 | PeptideAtlas
ProteomicsiTRAQ_TMT_Comparison_TMT10
IgY14/Supermix depletion, TMT10
ORGANISM(S): Homo Sapiens (human) 
2015-12-31 | PAe005315 | PeptideAtlas
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