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MetabolomicsHyperhomocysteinemia-related serum metabolome alterations not normalized by short-term folic acid treatment

Introduction

Hyperhomocysteinemia (HHCys) is an independent risk factor for various diseases such as cardiovascular diseases, Alzheimer's, and cancers. Folate deficiency is one of the significant reasons for HHCys. However, it is not known whether folate deficiency with HHCys is associated w...
2022-02-07 | MTBLS2150 | MetaboLights
UnknownB Cell Depletion Eliminates FVIII Memory B Cells and Enhances AAV8-coF8 Immune Tolerance Induction When Combined With Rapamycin.
Not available
S-EPMC7327091 | biostudies-literature
ProteomicsAlterations in the HLA-B*57:01 immunopeptidome by flucloxacillin and immunogenicity of drug-haptenated peptides
Flucloxacillin (FLX), a -lactam antibiotic for narrow-spectrum gram-positive bacterial infections, has been associated with severe immune-mediated drug-induced liver injury caused by an influx of T-lymphocytes targeting liver cells potentially recognizing drug-haptenated peptides in the context of H...
ORGANISM(S): Homo sapiens (Human) 
2021-02-17 | PXD024212 | Pride
Flucloxacillin Hla-b*57:01 Drug hypersensitivity Transgenic mice Hapten Immunogenicity 
UnknownFunctional redundancy in Echinocandin B in-cluster transcription factor ecdB of Emericella rugulosa NRRL 11440.
Not available
S-EPMC6036647 | biostudies-literature
TranscriptomicsFatty Acid Amide Hydrolase regulates peripheral B cell receptor revision, polyreactivity and B1 cells in lupus
FAAH expresson is induced in Sle2 splenic B cells. Increased peripheral B cell receptor revision, or selective peripheral expansion of BCR-revised B-cells, may lead to systemic autoimmunity, and FAAH is a lupus susceptibility gene that could regulate this process in Sle2 mice. To determine the gene ...
ORGANISM(S): Mus musculus 
2015-09-17 | E-GEOD-73112 | biostudies-arrayexpress
UnknownIdentification and characterization of genotype A and D recombinant hepatitis B virus from Indian chronic HBV isolates.
Not available
S-EPMC2761587 | biostudies-literature
UnknownVirtual screening of natural inhibitors to the predicted HBx protein structure of Hepatitis B Virus using molecular docking for identification of potential lead molecules for liver cancer.
Not available
S-EPMC4135291 | biostudies-literature
ProteomicsAurora kinase B-dependent phosphorylation regulates caspase-2 activity and function
Mitotic catastrophe (MC) is an important mechanism to remove cells that become polyploid or aneuploid, as an oncosuppressive mechanism. Previous studies have demonstrated that the activation and catalytic function of caspase-2 is a key step in MC, to trigger apoptosis and/or cell cycle arrest of suc...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD017866 | Pride
Aurorka kinase Caspase 2 Phosphorylation 
UnknownInhibition of protein kinases by anticancer DNA intercalator, 4-butylaminopyrimido[4',5':4,5]thieno(2,3-b)quinoline.
Not available
S-EPMC5430831 | biostudies-literature
UnknownInfluence of linker length in shape recognition of B* DNA by dimeric aminoglycosides.
Not available
S-EPMC4837466 | biostudies-literature
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