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ProteomicsFlucloxacillin-modified proteins identified in primary human hepatocytes
Flucloxacillin is a β-lactam antibiotic associated with a high incidence of drug-induced liver injury. Although expression of HLA-B*57:01 increases susceptibility, little is known of the pathological mechanisms involved in the induction of the clinical phenotype. Irreversible protein modification is...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD038581 | Pride
Primary human hepatocytes Flucloxaxillin Protein modification 
ProteomicsNaturally processed flucloxacillin haptenated HLA ligands
This study has demonstrated that natural flucloxacillin haptenated HLA-B*57:01 ligands arepresented by antigen presenting cells through multiple pathways. Identification of such epitopes will help to define the chemical signals responsible for drug-induced immunological disease.
ORGANISM(S): Homo sapiens (Human) 
2020-08-05 | PXD020137 | Pride
Dili Hla-b*57:01 Drug hypersensitivity Flucloxacillin 
UnknownIdentification of flucloxacillin-modified hepatocellular proteins: implications in flucloxacillin-induced liver injury.
Not available
S-EPMC10371196 | biostudies-literature
TranscriptomicsTranscription profiling of human liver in response to flucloxacilin-induced liver injury
Drug-induced liver injury (DILI) due to flucloxacillin is a rare but serious complication of treatment with this antimicrobial. The genetic basis of susceptibility is poorly understood as is the underlying molecular mechanism for disease. There is some evidence that flucloxacillin is a pregnane X re...
ORGANISM(S): Homo sapiens 
2009-12-01 | E-MEXP-2128 | biostudies-arrayexpress
UnknownHigh unbound flucloxacillin fraction in critically ill patients.
Not available
S-EPMC8598283 | biostudies-literature
ProteomicsAlterations in the HLA-B*57:01 immunopeptidome by flucloxacillin and immunogenicity of drug-haptenated peptides
Flucloxacillin (FLX), a -lactam antibiotic for narrow-spectrum gram-positive bacterial infections, has been associated with severe immune-mediated drug-induced liver injury caused by an influx of T-lymphocytes targeting liver cells potentially recognizing drug-haptenated peptides in the context of H...
ORGANISM(S): Homo sapiens (Human) 
2021-02-17 | PXD024212 | Pride
Flucloxacillin Hla-b*57:01 Drug hypersensitivity Transgenic mice Hapten Immunogenicity 
UnknownTarget attainment and population pharmacokinetics of flucloxacillin in critically ill patients: a multicenter study.
Not available
S-EPMC9982780 | biostudies-literature
UnknownImpact of SLCO1B1*5 on Flucloxacillin and Co-Amoxiclav-Related Liver Injury.
Not available
S-EPMC9214039 | biostudies-literature
UnknownDicloxacillin and flucloxacillin inhibit hepatic uptake transporters -in vitro investigations and physiologically based pharmacokinetic modelling.
Not available
S-EPMC12633417 | biostudies-literature
UnknownFlucloxacillin worsens while imipenem-cilastatin protects against vancomycin-induced kidney injury in a translational rat model.
Not available
S-EPMC10872794 | biostudies-literature
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