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GenomicsConserved epigenomic signatures between mouse and human elucidate immune basis of Alzheimer's disease
Alzheimer’s disease (AD) is a severe1 age-related neurodegenerative disorder characterized by accumulation of beta-amyloid (Aβ) plaques and neurofibrillary tangles, synaptic and neuronal loss, and cognitive decline. Several genes have been implicated in AD, but chromatin state alterations during ne...
ORGANISM(S): Mus musculus 
2015-02-18 | E-GEOD-65159 | biostudies-arrayexpress
GenomicsWhole genome mapping of STAT3 binding sites in the two major subtypes of diffuse large B cell lymphoma
The goal of this study is to identify the effect of the transcription factor STAT3 in the two major subtypes of diffuse large B cell lymphoma (DLBCL). STAT3 is a signal transducer that, when dysregulated, becomes a powerful oncogene found in many human cancers, including DLBCL. DLBCL is the most c...
ORGANISM(S): Homo sapiens 
2013-12-16 | E-GEOD-50723 | biostudies-arrayexpress
TranscriptomicsWhole transcriptome profiling of the two major subtypes of diffuse large B cell lymphoma
The goal of this study is to identify the transcriptome differences between the two major subtypes of diffuse large B cell lymphoma (DLBCL). DLBCL is the most common form of non-Hodgkin’s lymphoma and has two major subtypes: germinal center B-cell-like (GCB) and activated B-cell-like (ABC). When c...
ORGANISM(S): Homo sapiens 
2013-12-16 | E-GEOD-50721 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of S. cerevisiae response to Oxygen, Heme and Cobalt
Yeast cell growth and treatment:; Yeast strains used were L51 (MATa, ura3-52, leu2-3, 112, his4-519, ade1-100, trp1::HisG, hap1::LEU2) and MHY100 (MATa, ura3-52, leu2-3, 112, his4-519, ade1-100, hem1-delta100). L51 was used for studies of oxygen regulation, and MHY100 was used for studies of heme r...
ORGANISM(S): Saccharomyces cerevisiae 
2008-10-25 | E-GEOD-8343 | biostudies-arrayexpress
GenomicsNucleosome Position by MNase-seq from ENCODE/Stanford/BYU
This data was generated by ENCODE. If you have questions about the data, contact the submitting laboratory directly (Anshul Kundaje mailto:akundaje@stanford.edu). If you have questions about the Genome Browser track associated with this data, contact ENCODE (mailto:genome@soe.ucsc.edu). Nucleosomes ...
ORGANISM(S): Homo sapiens 
2012-04-20 | GSE35586 | GEO
Genomicsβ-catenin regulates primitive streak induction through collaborative interactions with SMAD2/3 and OCT4
Canonical Wnt and Nodal signaling are both required for induction of the primitive streak (PS), which guides organization of the early embryo. The Wnt effector β-catenin is thought to function in these early lineage specification decisions via transcriptional activation of Nodal signaling. Here, we ...
ORGANISM(S): Homo sapiens 
2015-03-31 | E-GEOD-58476 | biostudies-arrayexpress
GenomicsNucleosome Position by MNase-seq from ENCODE/Stanford/BYU
Nucleosomes are part of the first level of chromatin packaging. They each consist of a histone heterooctamer around which DNA wraps 1.6 times. The histone heterooctomamer is made up of two copies of histones 2A, 2B, 3 and 5. The segment of DNA wrapped around the histones, the so-called "core&qu...
ORGANISM(S): Homo sapiens 
2012-04-19 | E-GEOD-35586 | biostudies-arrayexpress
UnknownEpigenomic landscape of single vascular cells reflects developmental origin and disease risk loci
Not available
S-SCDT-10_1038-S44320-025-00140-2 | biostudies-other
GenomicsDiverse patterns of genome-wide DNA targeting by transcriptional regulators in Drosophila melanogaster
Understanding the regulatory genome remains a significant challenge. Annotation of regulatory elements and identification of the transcription factors (TFs) targeting these elements are key steps in understanding how a given cell interprets its genetic blueprint. One goal of the modENCODE (model or...
ORGANISM(S): Drosophila melanogaster 
2013-08-16 | E-GEOD-49899 | biostudies-arrayexpress
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