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TranscriptomicsSpecific inhibition of p300-HAT alters Global Gene Expression and Repress HIV replication
Reversible acetylation of histone and nonhistone proteins plays pivotal role in cellular homeostasis. Dysfunction of histone acetyltransferases (HATs) leads to several diseases including cancer, neurodegenaration, asthma, diabetes, AIDS and cardiac hypertrophy. We describe the synthesis and characte...
ORGANISM(S): Homo sapiens 
2010-06-11 | E-GEOD-7818 | biostudies-arrayexpress
TranscriptomicsNucleosome positioning in A549 cells before/after NME2 induction
Previous studies have analyzed patterns of transcription, transcription factor (TF) binding or mapped nucleosome occupancy across the genome. These suggest that the three aspects are genetically connected but the cause and effect relationships are still unknown. For example, physiologic TF binding ...
ORGANISM(S): Homo sapiens 
2014-08-04 | E-GEOD-40363 | biostudies-arrayexpress
TranscriptomicsInhibition of p300 Lysine Acetyltransferase activity by Luteolin reduces tumor growth in head and neck squamous cell carcinoma (HNSCC) xenograft mouse model [mRNA]
Chromatin acetylation is attributed with distinct functional relevance with respect to gene expression in normal and diseased conditions thereby leading to a topical interest in the concept of epigenetic modulators and therapy. We report here the identification and characterization of the acetylatio...
ORGANISM(S): Homo sapiens 
2016-07-05 | E-GEOD-75029 | biostudies-arrayexpress
UnknownPositive coactivator PC4 shows dynamic nucleolar distribution required for rDNA transcription and protein synthesis.
Not available
S-EPMC12167574 | biostudies-literature
TranscriptomicsA549 cells before/after NME2 induction
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-08-04 | E-GEOD-40433 | biostudies-arrayexpress
UnknownAtheroprotective roles of smooth muscle cell phenotypic modulation and the TCF21 disease gene as revealed by single-cell analysis.
Not available
S-EPMC7274198 | biostudies-literature
TranscriptomicsExpression profile of lung adenocarcinoma, A549 cells following targeted depletion of non metastatic 2 (NME2/NM23 H2)
Non-metastatic 2 (NME2) is an established metastases suppressor in multiple human cancer types. However, the molecular mechanisms of NME2 action remain insufficiently resolved. We recently validated the transcription regulatory activity of NME2 with respect to control of proto-oncogene c-MYC express...
ORGANISM(S): Homo sapiens 
2011-02-08 | E-GEOD-18182 | biostudies-arrayexpress
UnknownGeo-environmental factors and the effectiveness of mulberry leaf extract in managing malaria.
Not available
S-EPMC10491663 | biostudies-literature
UnknownDexamethasone in Hospitalized Patients with Covid-19.
Not available
S-EPMC7383595 | biostudies-literature
UnknownEffect of Hydroxychloroquine in Hospitalized Patients with Covid-19.
Not available
S-EPMC7556338 | biostudies-literature
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