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TranscriptomicsPulmonary gene and microRNA expression changes in mice exposed to benzo(a)pyrene by oral gavage
Polycyclic aromatic hydrocarbons (PAHs) are widely distributed, carcinogenic environmental contaminants produced as a consequence of the incomplete combustion of fossil fuels. Benzo[a]pyrene (BaP) is a very extensively studied prototypical PAH. We recently reported a complete lack of change in micro...
ORGANISM(S): Mus musculus 
2011-10-03 | E-GEOD-24751 | biostudies-arrayexpress
ProteomicsCharacterisation of the adhesome of patient-derived cutaneous squamous carcinoma cells
Interactions between cells and the extracellular matrix, mediated by integrin adhesion complexes (IACs), play key roles in cancer progression and metastasis. We report here systems-level changes in the adhesome during progression of a patient-derived cutaneous squamous cell carcinoma (cSCC). We foun...
ORGANISM(S): Homo sapiens (Human) 
2023-03-25 | PXD021492 | Pride
Cancer Adhesome Adhesion Human 
TranscriptomicsToxicogenomic Assessment of Liver Responses following subchronic exposure to furan in Fischer F344 rats [miRNA]
Furan is a widely used industrial chemical and a common contaminant in heated foods. Chronic furan exposure has been shown to cause cholangiocarcinoma and hepatocellular tumors at doses of 2 mg/kg bw/day with gender differences in frequency and severity. The hepatic transcriptional alterations induc...
ORGANISM(S): Rattus norvegicus 
2014-10-30 | E-GEOD-62807 | biostudies-arrayexpress
TranscriptomicsToxicogenomic Assessment of Liver Responses following subchronic exposure to furan in Fischer F344 rats [cRNA]
Furan is a widely used industrial chemical and a common contaminant in heated foods. Chronic furan exposure has been shown to cause cholangiocarcinoma and hepatocellular tumors at doses of 2 mg/kg bw/day with gender differences in frequency and severity. The hepatic transcriptional alterations induc...
ORGANISM(S): Rattus norvegicus 
2014-10-30 | E-GEOD-62806 | biostudies-arrayexpress
TranscriptomicsAcute hepatic transcriptional response in male mice following oral exposure to benzo(a)pyrene
Benzo(a)pyrene is a well-established human carcinogen in humans and rodents. In the present study, we sought to determine the dose- and time-dependent changes in gene expression upon oral exposure to benzo(a)pyrene. Adult male B6C3F1 mice were exposed to four doses of benzo(a)pyrene or vehicle contr...
ORGANISM(S): Mus musculus 
2015-07-01 | E-GEOD-43633 | biostudies-arrayexpress
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