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TranscriptomicsTranscription profiling of human squamous cell carcinoma of the head and neck cells reveals tumor growth and prognosis of squamous cell carcinoma of the head and neck is linked to protein kinase C alpha
Protein Kinase C alpha (PKC) is a critical mediator of cell signaling and cancer growth. We show that PKC inhibitors decrease proliferation in squamous cell carcinoma of the head and neck (SCCHN) cells and abrogate growth of SCCHN tumors in mouse xenografts. Analysis of gene expression arrays reveal...
ORGANISM(S): Homo sapiens 
2009-03-28 | E-GEOD-10299 | biostudies-arrayexpress
UnknownAssociation between circulating tumor cells and prognosis in patients with stage III melanoma with sentinel lymph node metastasis in a phase III international multicenter trial.
Not available
S-EPMC3478576 | biostudies-literature
TranscriptomicsProtein Kinase C Alpha Promotes Tumor Growth by Initiating a Feed-forward Network Involving miR-15a and Cyclin E
Protein Kinase C alpha (PKC) is associated with progression and poor prognosis in head and neck cancer. Previous studies have demonstrated that PKC sustains the proliferative signal by increasing cyclin E expression, leading to enhanced E2F target gene transcription and DNA synthesis. Here we show ...
ORGANISM(S): Homo sapiens 
2010-10-08 | E-GEOD-10301 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of upper beak primorida of five species of Darwins Finches to identify species and/or size specific transcripts
We used five different species of Darwin’s Finches (G. magnirostris, G. conirostris, G. fortis, G. scandens, G. difficilis). G. difficilis was used as a common reference and we polled RNA from 9 unrelated individuals of this species to lower variation. We used at least two unrelated individual embr...
ORGANISM(S): Geospiza magnirostris 
2022-11-21 | E-MEXP-702 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse liver in conditional knockouts of the tumor suppressor gene Apc identifies Wnt/bet-catenin signaling activation in hepatocytes
A "Cartes d'Identite des Tumeurs" (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net). Conditional Knockout mouse model for the tumor suppressor gene Ap, Apc 2lox. The disruption of the Apc gene is realized by injection of an adenovirus encoding the Cre recom...
ORGANISM(S): Mus musculus 
2006-03-13 | E-TABM-81 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human head and neck squamous cell carcinoma samples reveals a feed-forward loop involving protein kinase Calpha and microRNAs regulates tumor cell cycle
Patient selection and specimen collection. Thirty-six freshly frozen tumor samples were prospectively collected from patients undergoing surgery or biopsy for HNSCC at the University of North Carolina (UNC) at Chapel Hill (21 patients) and Vanderbilt University (15 patients). All tissues were snap-f...
ORGANISM(S): Homo sapiens 
2009-03-28 | E-GEOD-10300 | biostudies-arrayexpress
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