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TranscriptomicsDifferential regulation of SBF and MBF target genes by genotoxic stress occurs via Rad53-dependent inactivation of the MBF correpressor Nrm1
MBF and SBF transcription factors regulate a large family of coordinately expressed G1/S genes required for early cell cycle functions including DNA replication and repair. SBF is inactivated upon S phase entry by Clb/CDK whereas MBF targets are repressed by the corepressor, Nrm1. Using genome-wide ...
ORGANISM(S): Saccharomyces cerevisiae 
2012-02-15 | E-GEOD-33695 | biostudies-arrayexpress
TranscriptomicsDNA damage checkpoint kinases regulate a global network of transcription factors
DNA damage results in the activation of checkpoint kinases, which phosphorylate downstream effectors that inhibit the cell cycle, activate DNA repair, and cause widespread changes in transcription. However, the specific connections between the checkpoint kinases and downstream transcription factors ...
ORGANISM(S): Saccharomyces cerevisiae 
2013-03-31 | E-GEOD-40351 | biostudies-arrayexpress
TranscriptomicsEvolutionary divergence in the fungal response to fluconazole revealed by soft clustering (S. cerevisiae, C. glabrata, K. lactis)
Fungal infections are an emerging health risk, especially those involving yeast that are resistant to antifungal agents. To understand the range of mechanisms by which yeasts can respond to anti-fungals, we compared gene expression patterns across three evolutionarily distant species - Saccharomyces...
ORGANISM(S): Candida glabrata 
2010-07-08 | E-GEOD-15710 | biostudies-arrayexpress
TranscriptomicsCoeevolution of a transcriptional network by compensatory trans and cis mutations
Transcriptional networks have been shown to evolve very rapidly, prompting questions as to how such changes arise and are tolerated. Recent comparisons of transcriptional networks across species have implicated variations in the cis-acting DNA sequences near genes as the main cause of divergence. Wh...
ORGANISM(S): Candida glabrata 
2010-09-17 | E-GEOD-15818 | biostudies-arrayexpress
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