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TranscriptomicsIdentification of rheumatoid arthritis and osteoarthritis patients by transcriptome-based rule set generation
Discrimination of rheumatoid arthritis (RA) patients from patients with other inflammatory/degenerative joint diseases or healthy individuals purely on the basis of genes differentially expressed in high-throughput data has proven very difficult. Thus, the present study sought to achieve such discri...
ORGANISM(S): Homo sapiens 
2014-02-21 | E-GEOD-55235 | biostudies-arrayexpress
TranscriptomicsRNA-seq of Arabidopsis spl7 identifies two genes required for copper acquisition and a copper dependence of iron homeostasis
The transition metal copper (Cu) is an essential element for all living organisms. In plants, Cu plays key roles in electron transport chains of chloroplasts and mitochondria, as well as in cell wall metabolism, ethylene perception, molybdenum cofactor synthesis and oxidative stress protection. Beca...
ORGANISM(S): Arabidopsis thaliana 
2013-10-14 | E-GEOD-24696 | biostudies-arrayexpress
TranscriptomicsIdentification of rheumatoid arthritis and osteoarthritis patients by transcriptome-based rule set generation [Leipzig]
Discrimination of rheumatoid arthritis (RA) patients from patients with other inflammatory/degenerative joint diseases or healthy individuals purely on the basis of genes differentially expressed in high-throughput data has proven very difficult. Thus, the present study sought to achieve such discri...
ORGANISM(S): Homo sapiens 
2014-03-05 | E-GEOD-55584 | biostudies-arrayexpress
TranscriptomicsIdentification of rheumatoid arthritis and osteoarthritis patients by transcriptome-based rule set generation [Jena]
Discrimination of rheumatoid arthritis (RA) patients from patients with other inflammatory/degenerative joint diseases or healthy individuals purely on the basis of genes differentially expressed in high-throughput data has proven very difficult. Thus, the present study sought to achieve such discri...
ORGANISM(S): Homo sapiens 
2014-03-05 | E-GEOD-55457 | biostudies-arrayexpress
TranscriptomicsStimulation of RA SFBs with IL1 or PDGF-D
Synovial fibroblasts of 6 RA patients were treated with IL1 or PDGF-D. The aim of this study was to outline mechanism of the disease RA by a treatment with one of these cytokines. In total 6 patients were analyzed with 5 time points each (0h, 1h, 2h, 4h and 12h). The patients are biological replicat...
ORGANISM(S): Homo sapiens 
2014-08-10 | E-GEOD-58203 | biostudies-arrayexpress
TranscriptomicsLinking toxicant physiological mode of action with induced gene expression changes in Caenorhabditis elegans: atrazine
Physiologically based modelling using DEBtox (dynamic energy budget in toxicology) and transcriptional profiling were used in Caenorhabditis elegans to identify how physiological modes of action, as indicated by effects on system level resource allocation were associated with changes in gene express...
ORGANISM(S): Caenorhabditis elegans 
2010-03-23 | E-GEOD-21008 | biostudies-arrayexpress
TranscriptomicsLinking toxicant physiological mode of action with induced gene expression changes in Caenorhabditis elegans: cadmium
Physiologically based modelling using DEBtox (dynamic energy budget in toxicology) and transcriptional profiling were used in Caenorhabditis elegans to identify how physiological modes of action, as indicated by effects on system level resource allocation were associated with changes in gene express...
ORGANISM(S): Caenorhabditis elegans 
2010-05-05 | E-GEOD-21010 | biostudies-arrayexpress
TranscriptomicsLinking toxicant physiological mode of action with induced gene expression changes in Caenorhabditis elegans: fluoranthene
Physiologically based modelling using DEBtox (dynamic energy budget in toxicology) and transcriptional profiling were used in Caenorhabditis elegans to identify how physiological modes of action, as indicated by effects on system level resource allocation were associated with changes in gene express...
ORGANISM(S): Caenorhabditis elegans 
2010-05-05 | E-GEOD-21011 | biostudies-arrayexpress
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