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MetabolomicsPreoperative exercise induces anti-tumor Kupffer cells to prevent surgical stress-promoted colorectal cancer liver metastasis

Kupffer cells from both Sed and PEx mice were harvested for Metabolomics. 3 weeks after tumor injection, both mice bearing MC38 tumors were sacrificed. The livers were harvested and processed into single-cell suspensions, and KCs were isolated.

2025-12-09 | MTBLS13419 | MetaboLights
ProteomicsThe cellular and proteomic response of primary and immortalized murine Kupffer cells following immune stimulation diverges from that of monocyte-derived macrophages
Kupffer cells are the first line of defense in the liver against pathogens, yet several microbes successfully target the liver, bypass immune surveillance, and effectively develop in this tissue. Our current, albeit poor, understanding of Kupffer cell-pathogen interactions has been largely achieved ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-22 | MSV000079995 | MassIVE
TranscriptomicsKupffer cells promote hepatic steatosis via interleukin-1beta-dependent suppression of peroxisome proliferator-activated receptor alpha activity.
Kupffer cells have been implicated in the pathogenesis of various liver diseases. However, their involvement in metabolic disorders of the liver, including fatty liver disease, remains unclear. The present study sought to determine the impact of Kupffer cells on hepatic triglyceride storage and to e...
ORGANISM(S): Mus musculus 
2011-10-17 | E-GEOD-33044 | biostudies-arrayexpress
TranscriptomicsRNA-seq of Kupffer cells isolated from WT mice and Atg5-specific deficient Kupffer cells mice
Kupffer cells were sorted from the liver of WT mice and Atg5-specific deficient Kupffer cells mice. RNAs were extracted from the Kupffer cells and we performed an RNA-seq on these cells.
ORGANISM(S): Mus musculus 
2026-03-24 | E-MTAB-15260 | biostudies-arrayexpress
TranscriptomicsInfiltrating monocyte-derived macrophages and resident kupffer cells display different ontogeny and functions in acute liver injury
Molecular profiling of infiltrating monocyte-derived macrophages versus resident kupffer cells following acute liver injury The liver has a remarkable capacity to regenerate after injury; yet, the role of macrophages (MF) in this process remains controversial mainly due to difficulties in distinguis...
ORGANISM(S): Mus musculus 
2014-08-01 | E-GEOD-55606 | biostudies-arrayexpress
TranscriptomicsRNAseq of sorted Kupffer cells during ulcerative colitis
Ulcerative colitis impact on Kupffer cell homeostasis was assessed using transcriptional analysis. Kupffer cells were sorted from the livers of mice treated with dextran sodium sulphate for 7 days. Total RNA preparation was performed on 20,000 sorted Kupffer cells.
ORGANISM(S): Mus musculus 
2026-09-02 | E-MTAB-15568 | biostudies-arrayexpress
TranscriptomicsImpact of inducing hypercholesterolemia on Kupffer cells
Kupffer cells (KCs) are the largest tissue resident macrophage population in direct contact with blood and thus with circulating lipoproteins. How KCs homeostasis is affected by the build-up of cholesterol-rich lipoproteins in the context of hypercholesterolemia has been poorly investigated. In this...
ORGANISM(S): Mus musculus 
2024-09-05 | E-MTAB-12611 | biostudies-arrayexpress
TranscriptomicsBone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells
Self-renewing tissue-resident macrophages are thought to be exclusively derived from embryonic progenitors. However, whether circulating monocytes can also give rise to such macrophages has not been formally investigated. Here we use a new model of diphtheria toxin-mediated depletion of liver-reside...
ORGANISM(S): Mus musculus 
2015-11-21 | E-GEOD-75225 | biostudies-arrayexpress
ProteomicsThe cellular and proteomic response of primary and immortalized murine Kupffer cells following immune stimulation diverges from that of monocyte-derived macrophages
Kupffer cells are the first line of defense in the liver against pathogens, yet several microbes successfully target the liver, bypass immune surveillance, and effectively develop in this tissue. Our current, albeit poor, understanding of Kupffer cell-pathogen interactions has been largely achieved ...
ORGANISM(S): Homo sapiens (Human) 
2015-07-03 | PXD001247 | Pride
Cytoskeleton  kupffer cell  macrophage  malaria  murine 
ProteomicsCOMPARATIVE ANALYSIS OF THE PROTEOME OF KUPFFER CELLS AND MONOCYTES
Macrophage population in most mammalian organs consists of cells of different origin, with the exception of the central nervous system and the liver, where macrophages of monocytic origin are almost completely absent. The reasons for such distribution and the phenomenon of coexistence of the two sep...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD018586 | Pride
Kuppfer cells Macrophages Monocytes 
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