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UnknownData set of Aspergillus flavus induced alterations in tear proteome: Understanding the pathogen-induced host response to fungal infection.
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S-EPMC5109265 | biostudies-literature
ProteomicsAspergillus flavus Induced Alterations in Tear Protein Profile Reveal Pathogen-Induced Host Response to Fungal Infection
Aspergillus flavus and Fusarium sp. are primary causative agents of keratitis that results in corneal tissue damage leading to vision loss. The tear proteome of control and keratitis patients was profiled and compared. A total of 1873 proteins from control and 1400 proteins from patient tear were id...
ORGANISM(S): Homo sapiens (Human) 
2016-12-13 | PXD003825 | Pride
Mycotic keratitis  tear proteomics  complement  netosis  wound healing  glycosylation 
ProteomicsDepletion of melanin exposes Aspergillus flavus conidial surface proteins and alters the surface architecture and virulence.
A. flavus keratitis is one of the predominant fungal infections affecting the tropical parts of the world. Melanin is a virulence factor in numerous pathogenic fungi and the melanin layer maintains the cell wall structure and provides chemical and physical protection to the organism. However, the mo...
ORGANISM(S): Aspergillus flavus FRR 3643 
2024-05-23 | PXD037707 | Pride
Non-melanized conidia Melanized conidia Melanin And surface protein 
ProteomicsIdentification of the early exoproteome of pathogenic Aspergilli, Aspergillus flavus and Aspergillus fumigatus
We identified the proteins secreted by A. flavus and A. fumigatus conidia during the early stages of growth. A comparative analysis was done between the exoproteome of the two species to identify the core proteins that were common between the two Aspergilli as well as species specific signature prot...
ORGANISM(S): Aspergillus fumigatus Af293 Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167) 
2025-01-17 | PXD012982 | Pride
Conidia A. flavus A. fumigatus Exoproteome 
ProteomicsHuman corneal epithelial cells internalize Aspergillus flavus spores by actin mediated endocytosis
Mycotic leratitis is the corneal inflammation predominantly caused by Fusarium and Aspergillus species. Corneal epithelium is the earliest cell type encounter the invading pathogen. The innate immune responses of human corneal epithelial cells against Aspergillus flavus is not known. Here we studied...
ORGANISM(S): Homo sapiens (Human) 
2021-04-07 | PXD019512 | Pride
Corneal epithelium Actin ring Asperillus flavus Phagosome 
ProteomicsComparison of the rodlet layer proteins of Aspergillus flavus and Aspergillus fumiguatus
Atomic force microscopy (AFM) imaging showed that the rodlet layer of A. fumigatus and A. flavus was different. The objective of this project was to examine the differences in the rodlet layer of these two pathogenic Aspergillus species.
ORGANISM(S): Aspergillus flavus FRR 342 Aspergillus fumigatus Af293 
2021-09-09 | PXD020592 | Pride
Roda A. fumigatus Rodlet layer A.flavus 
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