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TranscriptomicsTranscription profiling of human adult to adult living donor liver grafts compared to deceased donor grafts
Because of inherent differences between deceased donor (DD) and living donor (LD) liver grafts, we hypothesize that the molecular signatures will be unique, correlating with specific biologic pathways and clinical patterns. Following reperfusion, 579 genes in DD grafts and 1324 genes in LDs were ...
ORGANISM(S): Homo sapiens 
2009-06-23 | E-GEOD-12720 | biostudies-arrayexpress
TranscriptomicsGene Expression in Biopsies of Acute Rejection and Interstitial Fibrosis/Tubular Atrophy Reveals Highly Shared Mechanisms that Correlate with Worse Long-term Outcomes
Rationale: Interstitial fibrosis and tubular atrophy (IFTA) is found in ~25% of 1-year biopsies post-transplant(1, 2). It correlates with decreased graft survival when histological evidence of inflammation is present¬.(3-5) Identifying the etiology of IFTA is important because longterm graft surviva...
ORGANISM(S): Homo sapiens 
2016-01-15 | E-GEOD-76882 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human blood from kidney transplant patients to identify biomarkers for early and late stage chronic allograft nephropathy by genomic profiling
Despite significant improvements in life expectancy of kidney transplant patients due to advances in surgery and immunosuppression, Chronic Allograft Nephropathy (CAN) remains a daunting problem. A complex network of cellular mechanisms in both graft and peripheral immune compartments complicates th...
ORGANISM(S): Homo sapiens 
2009-07-19 | E-GEOD-12187 | biostudies-arrayexpress
TranscriptomicsA Gene Expression-based Blood Diagnostic for Symptomatic Transthyretin Amyloidosis Revealing Male and Female-specific Signatures
Early diagnosis of transthyretin (TTR) amyloid diseases remains challenging because of variable disease penetrance. Currently, patients must have an amyloid positive tissue biopsy to be eligible for disease modifying therapies. Early diagnosis is often difficult because the patient exhibits apparent...
ORGANISM(S): Homo sapiens 
2016-08-09 | E-GEOD-67784 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of laparoscopic donor nephrectomy samples compared to healthy control kidneys
We compared gene expression profiles from six donor kidneys prior to surgical manipulation to six kidneys removed after laparoscopic donor nephrectomy (LDN) and several hours of CO2 pneumoperitoneum. Biopsies were obtained from renal cortex and hybridized to Affymetrix HG-U133A GeneChips. For cont...
ORGANISM(S): Homo sapiens 
2005-09-14 | E-GEOD-3297 | biostudies-arrayexpress
TranscriptomicsDe novo kidney transplantation without use of calcineurin inhibitors preserves renal structure and function
Background: Despite significant improvements in short-term kidney transplant survival, comparable increases in 5 and 10-year outcomes have not been achieved. Chronic allograft nephropathy (CAN) is a major cause of late graft loss. Toxic nephropathy and inadequate long-term immunosuppression are poss...
ORGANISM(S): Homo sapiens 
2004-09-23 | E-GEOD-1743 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat syngeneic (sTX) and allogeneic kidney (aTX) transplantation compared to control (ctr) kidneys
Microarray analyses provide a powerful approach to identify gene expression alterations following kidney transplantation. However, the heterogeneity of human kidney transplant specimens and the variation in sample preparation precludes conclusions regarding the underlying mechanisms of the observed ...
ORGANISM(S): Rattus norvegicus 
2008-06-14 | E-GEOD-6497 | biostudies-arrayexpress
TranscriptomicsKidney Transplant Rejection and Tissue Injury by Gene Profiling of Biopsies and Peripheral Blood Lymphocytes
We used DNA microarrays (HG-U95Av2 GeneChips) to determine gene expression profiles for kidney biopsies and peripheral blood lymphocytes (PBLs) in transplant patients. Sample classes include kidney biopsies and PBLs from patients with 1) healthy normal donor kidneys, 2) well-functioning transplants ...
ORGANISM(S): Homo sapiens 
2004-07-14 | E-GEOD-1563 | biostudies-arrayexpress
UnknownApolipoprotein B, Residual Cardiovascular Risk After Acute Coronary Syndrome, and Effects of Alirocumab.
Not available
S-EPMC9422774 | biostudies-literature
UnknownLipoprotein(a) and Benefit of PCSK9 Inhibition in Patients With Nominally Controlled LDL Cholesterol.
Not available
S-EPMC8822604 | biostudies-literature
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