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TranscriptomicsMicroarray evidence for off target effects and the optimisation of targeted RNAi mediated gene silencing in the cattle tick Rhipicephalus (Boophilus) microplus
The NimbleGen cattle tick custom microarray based on the BmiGI.V2 database of R. microplus ESTs was used to screen the resulting mRNA harvested from ticks treated with the tick Ubiquitin-63E 600bp dsRNA in comparison to controls. A total of 144 ESTs including TC6372 (Ubiquitin-63E) were down-regulat...
ORGANISM(S): Rhipicephalus microplus 
2011-07-30 | E-GEOD-27453 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of round spermatids comparing WT (FVBNJ) to H2A.B3 knock-out mice
The histone variant H2A.B3 (H2A.Bbd/H2A.Lap1) has a tissue-specific expression pattern and is found to be most highly expressed during spermatogenesis. In order to investigate the role of H2A.B3 in chromatin packaging and regulation of spermatogenesis we created a line of TALEN-edited FVBN mice in w...
ORGANISM(S): Mus musculus 
2019-01-04 | E-MTAB-7277 | biostudies-arrayexpress
TranscriptomicsEffects of Plasmodium berghei infection on Anopheles gambiae during oocysts development
Plasmodium ssp. are pathogens in their vertebrate hosts and also cause deleterious effects to their insect vectors. We show here, however, that Plasmodium-infected mosquitoes more efficiently accumulate energy resources (glycogen) during oocyst development, and survive better when they are starved. ...
ORGANISM(S): Anopheles gambiae 
2011-12-31 | E-GEOD-32200 | biostudies-arrayexpress
Genomicsena-DATASET-EORTC-22-06-2015-15:48:20:114-204 - samples
Data represent genome-wide DNA methylation profiles obtained by MethylCap-seq (Diagenode’s MethylCap-kit based purification followed by Illumina GAIIx sequencing), for 70 brain tissue samples, including 65 glioblastoma samples and 5 non-tumoral tissues (obtained from epilepsy surgery).
EGAD00001001399 | EGA
GenomicsGenome-wide DNA-methylation assessment by MethylCap-seq and Infinium HumanMethylation450 BeadChips: an independent large-scale comparison
DNA-methylation is an important epigenetic feature in health and disease. Two cost-efficient genome-scale methodologies to assess DNA-methylation are MethylCap-seq and Illumina's Infinium HumanMethylation450 BeadChips (HM450). However, objective information regarding the best-suited methodology for ...
EGAS00001001191 | EGA
GenomicsEORTC Data Sharing DAC
Data Access Committee EGAC00001001818
EGAC00001001818 | EGA
TranscriptomicsBAC aCGH profiling of 64 GBM (primary & recurrent)
aCGH was used to profile copy-number aberrations (CNA) in 64 glioblastoma specimen of patients treated within clinical trials. The data was used to identify changes in CNA which contribute to the aberrant of expression of HOX transcription factors. Our group had previously demonstrated that expressi...
ORGANISM(S): Homo sapiens 
2015-01-06 | E-GEOD-60507 | biostudies-arrayexpress
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