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TranscriptomicsTranscription profiling of rat pancreatic beta-cells in response to cytokine exposure and NF-kappa B activation blocking
Type 1 diabetes mellitus results from an autoimmune destruction of pancreatic beta-cells. Based on findings suggesting NF-kappa B plays a role in beta cell apoptosis, we blocked NF-kappa B activation in cytokine-exposed FACS sorted beta cells by a recombinant adenovirus (AdI kappa B((SA)2)) containi...
ORGANISM(S): Rattus norvegicus 
2006-06-16 | E-CBIL-9 | biostudies-arrayexpress
TranscriptomicsDetailed transcriptome atlas of the pancreatic beta cell
The aim of the present study was to explore the transcriptome of pancreatic islets and, based on this information, to prepare a comprehensive and open access inventory of insulin-producing ?-cell gene expression, the beta-Cell Gene Atlas (BCGA). INS-1 cells, primary rat beta-cells (>87% beta-cells) ...
ORGANISM(S): Rattus norvegicus 
2008-12-31 | E-GEOD-13381 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human islets after in vitro expansion.
Pancreatic islet transplantation as a cure for type 1 diabetes (T1D) cannot be scaled up due to a scarcity of human pancreas donors. In vitro expansion of beta cells from mature human pancreatic islets provides an alternative source of insulin-producing cells. The exact nature of the expanded cells ...
ORGANISM(S): Homo sapiens 
2009-08-07 | E-GEOD-15543 | biostudies-arrayexpress
UnknownLongitudinal Changes in the Structure of Speech Categorization Across School Age Years: Children Become More Gradient and More Consistent.
Not available
S-EPMC12583890 | biostudies-literature
UnknownAssessing quality of life in anal fistula patients after Seton placement using different knot types: Randomized controlled trial.
Not available
S-EPMC12855371 | biostudies-literature
no omics definedTranscription profiling of rat pancreatic beta-cells in response to double stranded RNA and IFNgamma exposure
Viral infections and local production of IFNgamma might contribute to beta-cell dysfunction/death in Type 1 diabetes. Double stranded RNA accumulates in the cytosol of viral-infected cells, and exposure of purified rat beta cells to dsRNA (polyinosinic-polycytidylic acid, PIC) in combination with IF...
ORGANISM(S): Rattus norvegicus 
2006-06-20 | E-CBIL-11 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat insulinoma-beta (INS-1E) cells exposed to the cytokines IL-1-beta and IFN-gamma for six different lengths of time and with or without the inducible NO synthase blocker NMA
Locally released cytokines contribute to beta cell dysfunction and apoptosis in Type 1 diabetes. In vitro exposure of insulin producing INS-1E cells to the cytokines interleukin (IL)-1beta + interferon (IFN) gamma leads to a significant increase in apoptosis. To characterize the genetic networks im...
ORGANISM(S): Rattus norvegicus 
2006-06-14 | E-CBIL-10 | biostudies-arrayexpress
UnknownFormulation of Fiber-Enriched Crackers with Oleaster Powder: Effect on Functional, Textural, and Sensory Attributes.
Not available
S-EPMC11870954 | biostudies-literature
UnknownQuantum Chemical Calculations, Topological Properties, ADME/Molecular Docking Studies, and Hirshfeld Surface Analysis on Some Organic UV-Filters.
Not available
S-EPMC12019759 | biostudies-literature
UnknownHeterotic grouping of wheat hybrids based on general and specific combining ability from line × tester analysis.
Not available
S-EPMC11438435 | biostudies-literature
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