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ProteomicsFidelity of translation initiation is required for coordinated respiratory complex assembly
Mammalian mitochondrial ribosomes are unique molecular machines that translate 11 leaderless mRNAs. To date it is not clear how mitoribosomes recognize and initiate translation in the absence of untranslated regions in the mitochondrial mRNAs. Translation initiation in mitochondria shares similariti...
ORGANISM(S): Mus musculus (Mouse) 
2020-01-02 | PXD015521 | Pride
Ribosome Translation Cardiomyopathy Rna-seq 
ProteomicsMitochondrial mistranslation is modulated by metabolic stress
Changes in the rate and fidelity of mitochondrial protein synthesis impact the metabolic and physiological roles of mitochondria. Here we explored how environmental stress in the form of a high fat diet modulates mitochondrial translation using mutant mice with error-prone (Mrps12ep/ep) or hyper-acc...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD021762 | Pride
Metabolism Mitochondria Protein synthesis 
TranscriptomicsHierarchical RNA processing is rate limiting for mitochondrial ribosome assembly
In animals the organization of the compact mitochondrial genome and lack of introns have necessitated a unique mechanism for RNA processing. To date the regulation of mitochondrial RNA processing and its importance for ribosome biogenesis and energy metabolism are not clear. To understand the in viv...
ORGANISM(S): Mus musculus 
2016-08-04 | E-GEOD-83471 | biostudies-arrayexpress
ProteomicsComparative shotgun proteomics of aqueous humor for cataract, glaucoma and pseudoexfoliation eye disorders.
The aim of this work was to characterize proteome of aqueous humor from subjects with various eye conditions such as cataract, glaucoma and pseudoexfoliation syndrome by high-resolution chromate-mass-spectrometry. Twenty nine human aqueous humor samples were processed by shotgun proteomics. Data was...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080838 | MassIVE
ProteomicsSequence coverage by multiple reads in shotgun proteomics to validate single amino acid variants
Mass spectrometry-based shotgun proteomics is currently based on assigning matches between mass-spectra of protein fragments resulting from protease digestion and amino acid sequences predicted from nucleic acid sequences. At the same time, the method lacks reliability in identification of every sin...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-12-07 | MSV000088536 | MassIVE
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