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TranscriptomicsA dysregulated Acetyl/SUMO switch of FXR promotes hepatic inflammation in obesity
Acetylation of transcriptional regulators is normally dynamically regulated by nutrient status but is often persistently elevated in nutrient-excessive obesity conditions. We investigated the functional consequences of such aberrantly elevated acetylation of the nuclear receptor FXR as a model. Prot...
ORGANISM(S): Mus musculus 
2014-10-17 | E-GEOD-62414 | biostudies-arrayexpress
TranscriptomicsRole of Cryptococcus neoformans Sre1-pathway in low oxygen gene expression
Comparison of wild-type serotype A C. neoformans cells grown at 21% and 3% oxygen for 2 hours in rich medium. Also comparison of wild-type and Sre1-pathway mutant strains grown at 3 % oxygen for 2 hours in rich medium. Two-condition experiment. Each comparison was performed in two biological replic...
ORGANISM(S): Filobasidiella neoformans 
2010-05-22 | E-GEOD-18282 | biostudies-arrayexpress
UnknownEarly Correction of N-Methyl-D-Aspartate Receptor Function Improves Autistic-like Social Behaviors in Adult Shank2-/- Mice.
Not available
S-EPMC6420362 | biostudies-literature
UnknownChemically and biologically synthesized CPP-modified gelonin for enhanced anti-tumor activity.
Not available
S-EPMC3849409 | biostudies-literature
UnknownImpact of Neighborhood Disadvantage on Tumor Biology and Breast Cancer Survival.
Not available
S-EPMC11611249 | biostudies-literature
UnknownRegulatory B-Cells Are Associated Negatively With Regulatory T-Cells and Positively With Cytokines in Peripheral Blood of Pregnant Women.
Not available
S-EPMC12001748 | biostudies-literature
UnknownOlder Ethnic Minority Women's Perceptions of Stroke Prevention and Walking.
Not available
S-EPMC4690776 | biostudies-literature
GenomicsRAG Represents a Widespread Threat to the Lymphocyte Genome - (Mnase-seq)
The RAG1 endonuclease, together with its cofactor RAG2, is essential for V(D)J recombination but is a potent threat to genome stability. The sources of RAG1 mistargeting and the mechanisms that have evolved to suppress it are poorly understood. Here, we report the surprising finding that RAG1 bind...
ORGANISM(S): Mus musculus 
2015-08-06 | E-GEOD-69474 | biostudies-arrayexpress
TranscriptomicsRAG Represents a Widespread Threat to the Lymphocyte Genome - (RNA-seq)
The RAG1 endonuclease, together with its cofactor RAG2, is essential for V(D)J recombination but is a potent threat to genome stability. The sources of RAG1 mistargeting and the mechanisms that have evolved to suppress it are poorly understood. Here, we report the surprising finding that RAG1 bind...
ORGANISM(S): Mus musculus 
2015-08-06 | E-GEOD-69473 | biostudies-arrayexpress
GenomicsRAG Represents a Widespread Threat to the Lymphocyte Genome - (ChIP-seq)
The RAG1 endonuclease, together with its cofactor RAG2, is essential for V(D)J recombination but is a potent threat to genome stability. The sources of RAG1 mistargeting and the mechanisms that have evolved to suppress it are poorly understood. Here, we report the surprising finding that RAG1 bind...
ORGANISM(S): Mus musculus 
2015-08-06 | E-GEOD-69475 | biostudies-arrayexpress
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