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MetabolomicsMetabolic adaptation of diatoms to hypersalinity

Microalgae are important primary producers and form the basis for the marine food web. As global climate changes, so do salinity levels that algae are exposed to. A metabolic response of algal cells partly alleviates the resulting osmotic stress. Some metabolites involved in the response are well...

2023-09-04 | MTBLS3177 | MetaboLights
MetabolomicsMetabolite Correlation Networks Reveal Complex Phenotypes of Adaptation-Driving Mutations

Living organisms are organized into hierarchical levels of increasing complexity. As mutational effects propagate through these levels, multiple phenotypes are produced. However, identifying which phenotypes influence fitness and drive selection remains a key challenge in understanding genotype-p...

2026-08-10 | MTBLS14569 | MetaboLights
MetabolomicsAdaptation of gut microbiome and host metabolic systems to lignocellulosic degradation in bamboo rats

Bamboo rats (Rhizomys pruinosus) are among the few mammals that lives on a bamboo-based diet which is mainly composed of lignocellulose. However, the mechanisms of adaptation of their gut microbiome and metabolic systems in the degradation of lignocellulose are largely unknown. Here, we ...

2022-04-22 | MTBLS4161 | MetaboLights
MetabolomicsMuscle metabolic resilience and enhanced exercise adaptation by Esr1-induced remodeling of mitochondrial cristae-nucleoid architecture in males

Reduced estrogen action is associated with obesity and insulin resistance. However, the cell and tissue-specific actions of estradiol in maintaining metabolic health remain inadequately understood, especially in men. We observed that skeletal muscle ESR1/Esr1 (encodes estrogen receptor α) is posi...

2025-04-09 | MTBLS914 | MetaboLights
MetabolomicsATF6 activation alters colonic lipid metabolism causing tumor-associated microbial adaptation

The induction of endoplasmic reticulum unfolded protein responses (UPRER) contributes to cancer development and progression. We recently linked microbiota-related triggers to the tumor-promoting role of signal transducer activating transcription factor 6 (ATF6) in the colon. Here we substantiate ...

2025-07-02 | MTBLS7387 | MetaboLights
MetabolomicsDefined microbiota modulates host metabolome and skeletal adaptation to diet-induced obesity

Background

The gut microbiota is increasingly recognized as a regulator of host metabolism and bone physiology. However, how microbial colonization integrates systemic metabolic cues with skeletal remodeling under metabolic stress remains unclear.

Results

We used germ-free (GF) ...

2025-11-25 | MTBLS13384 | MetaboLights
ProteomicsYersinia pestis Yp2126 laboratory domestication
Project goal is to describe proteomic changes arising from adaptation to laboratory culture conditions.
ORGANISM(S): Yersinia pestis CO92 
2016-01-12 | PXD002961 | Pride
Yersinia pestis evolution adaptation 
MetabolomicsDetoxification metabolic adaptation of Bombyx mori to artificial diet and functional study of key detoxification gene BmGSTd2

The exceptional adaptability of insects to diverse food sources is central to their survival and evolutionary success. However, the molecular mechanisms underlying this rapid adaptation remain largely uncharacterized. In this study, adaptive phenotypic, transcriptomic, and metabolomic differences...

2026-01-27 | MTBLS13782 | MetaboLights
MetabolomicsDual Effects of Fasting on Gut Microbiota and Metabolism: Protective Adaptation versus Barrier Dysfunction Risks
Fasting is increasingly recognized as a metabolic intervention that reshapes gut microbiota and host metabolism, but its duration-dependent effects on intestinal epithelial integrity remain incompletely understood. In this study, we compared ad libitum feeding, 12 h fasting, and 24 h fasting in male...
2026-07-20 | MTBLS15098 | MetaboLights
ProteomicsLaboratory adaptation of Bacillus anthracis
The spore forming pathogen Bacillus anthracis is the etiologic agent of anthrax in humans and animals. It cycles through infected hosts as vegetative cells and is eventually introduced into the environment where it generates an endospore resistant to many harsh conditions. The endospores are subsequ...
ORGANISM(S): Bacillus anthracis str. Ames 
2018-12-04 | PXD010120 | Pride
Shotgun proteomics Anthrax Evolution Sporulation Bacillus anthracis 
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