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ProteomicsA proteomic approach for characterizing trastuzumab-emtansine modified for nuclear directed localization that enhances cytotoxicity identifies regulatory nuclear transport receptor.
We used the approved antibody-drug conjugate trastuzumab-emtansine and the HER2+ cell line SKBR3. We also used a novel technology termed cell accumulator (Accum) that enables mAbs to escape endosome entrapment and localize to the cell nucleus without abrogating antibody affinity or specificity to ta...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD014786 | Pride
Nano-lc-ms/ms Antibody-drug conjugate Sk-br-3 Nuclear transport Protein-protein interaction Affinity purification 
Unknown2023 Canadian Surgery Forum: Sept. 20-23, 2023.
Not available
S-EPMC10718225 | biostudies-literature
UnknownEffect of a 24-Month Physical Activity Intervention vs Health Education on Cognitive Outcomes in Sedentary Older Adults: The LIFE Randomized Trial.
Not available
S-EPMC4698980 | biostudies-literature
UnknownPromoting physical activity for elders with compromised function: the lifestyle interventions and independence for elders (LIFE) study physical activity intervention.
Not available
S-EPMC3775623 | biostudies-literature
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