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ProteomicsProteomic profiling of embryonic retina to facilitate ocular disease gene discovery
To expedite gene discovery in eye development and its associated defects, we previously developed a bioinformatics resource-tool iSyTE (integrated Systems Tool for Eye gene discovery). However, iSyTE is presently limited to lens tissue and is predominantly based on transcriptomics datasets. Therefor...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-09 | PXD039490 | Pride
Gene discovery Proteome Embryogenesis Retina Mass spectrometry Isyte Development 
UnknownRNA-binding proteins and post-transcriptional regulation in lens biology and cataract: Mediating spatiotemporal expression of key factors that control the cell cycle, transcription, cytoskeleton and transparency.
Not available
S-EPMC8792301 | biostudies-literature
TranscriptomicsDevelopmental timecourse of mouse ocular lens and whole embryo control
Identification of genes involved in ocular birth defects remains a challenge. To facilitate the identification of genes associated with cataract, we developed iSyTE (integrated Systems Tool for Eye gene discovery; http://bioinformatics.udel.edu/Research/iSyTE). iSyTE contains microarray gene express...
ORGANISM(S): Mus musculus 
2012-02-16 | E-GEOD-32334 | biostudies-arrayexpress
UnknownMolecular characterization of the human lens epithelium-derived cell line SRA01/04.
Not available
S-EPMC6867612 | biostudies-literature
TranscriptomicsGenome-wide analysis of Tdrd7 knockdown in lens epithelial-derived cell line 21EM15
Analysis of Tdrd7 deficiency in mouse lens epithelial-derived cell line at gene expression level. The hypothesis tested was that Tdrd7 is involved in post-transcriptional control of gene expression in the lens. Results provide evidence for differential regulation of genes involved in lens homeostasi...
ORGANISM(S): Mus musculus 
2012-02-21 | E-GEOD-25774 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of 4-day old (P4) Tdrd7 null mouse lens
Analysis of Tdrd7 deficiency in mouse lens epithelial-derived cell line at gene expression level. The hypothesis tested was that Tdrd7 is involved in post-transcriptional control of gene expression in the lens. Results provide evidence for differential regulation of genes involved in lens homeostasi...
ORGANISM(S): Mus musculus 
2012-02-21 | E-GEOD-25775 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of 1 month old (P30) Tdrd7 null mouse lens
Analysis of Tdrd7 deficiency in mouse lens epithelial-derived cell line at gene expression level. The hypothesis tested was that Tdrd7 is involved in post-transcriptional control of gene expression in the lens. Results provide evidence for differential regulation of genes involved in lens homeostasi...
ORGANISM(S): Mus musculus 
2012-02-21 | E-GEOD-25776 | biostudies-arrayexpress
UnknownA zebrafish model of foxe3 deficiency demonstrates lens and eye defects with dysregulation of key genes involved in cataract formation in humans.
Not available
S-EPMC6020821 | biostudies-literature
UnknownRNA sequencing-based transcriptomic profiles of embryonic lens development for cataract gene discovery.
Not available
S-EPMC6342005 | biostudies-literature
UnknownProteomic profiling of retina and retinal pigment epithelium combined embryonic tissue to facilitate ocular disease gene discovery.
Not available
S-EPMC10680127 | biostudies-literature
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