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MetabolomicsGPR109a-AMPK Axis Mediates the Attenuation of Uric Acid-Induced M1 Macrophage Polarization by β-hydroxybutyrate from Lacticaseibacillus rhamnosus M2b

Hyperuricemia (HUA) is a metabolic disorder marked by increased blood uric acid (UA) levels, closely linked to conditions such as gout. UA-induced macrophage M1 polarization fundamentally exacerbates inflammatory pathophysiology, but current HUA-specific immunoregulatory treatments are inadequat...

2026-01-26 | MTBLS13224 | MetaboLights
ProteomicsAdaptation of Lacticaseibacillus rhamnosus CM MSU 529 to aerobic and respiratory growth: a proteomic approach
Lacticaseibacillus rhamnosus CM MSU 529 is the O2-tolerant facultative homofermentative lactic acid bacteria realizing respiratory metabolism when grown in a supplemented with hemin and vitamin K2 nutrient medium. This study describes the effect of aerobic and respiratory conditions on biomass and p...
ORGANISM(S): Lacticaseibacillus rhamnosus LRHMDP2 
2023-03-11 | PXD038847 | Pride
Lacticaseibacillus rhamnosus  aerobic conditions  respiratory conditions  oxidative stress  pyruvate oxidase  pyridoxine 5'-phosphate oxidase  nadh peroxidase  acetolactate synthase 
MetabolomicsLactobacillus rhamnosus B16 Regulates Lipid Metabolism Homeostasis by Producing Acetic Acid

Background Hyperlipidemia, a chronic disorder caused by abnormal lipid metabolism, increases risks of atherosclerosis and cardiovascular diseases. 

Current single-target drugs have limited efficacy and side effects, prompting interest in probiotics like Lactobacillus rhamnosus, though ...

2025-08-14 | MTBLS12858 | MetaboLights
TranscriptomicsDose-dependent immunomodulation of human dendritic cells by the probiotic Lactobacillus rhamnosus Lcr35
Gene expression changes in human dendritic cells after contact with either 10e4 or 10e7 CFU of Lactobacillus rhamnosus Lcr35 Bacterial cells were incubated for 3 hours with dendritic cells. Total RNA was extracted, quantified, and labeled with Cy3 or Cy5 (control, dendritic cells without bacteria). ...
ORGANISM(S): Homo sapiens 
2011-03-01 | E-GEOD-25699 | biostudies-arrayexpress
GenomicsLacticaseibacillus rhamnosus
Lacticaseibacillus rhamnosus Genome sequencing
PRJNA1121088 | ENA
GenomicsLacticaseibacillus rhamnosus
Lacticaseibacillus rhamnosus Genome sequencing
PRJNA769996 | ENA
GenomicsLacticaseibacillus rhamnosus breed:Procaryotic organism
Lacticaseibacillus rhamnosus breed:Procaryotic organism Genome sequencing and assembly
PRJNA861922 | ENA
GenomicsLacticaseibacillus rhamnosus
Lacticaseibacillus rhamnosus Genome sequencing
PRJNA947330 | ENA
GenomicsLacticaseibacillus rhamnosus
Lacticaseibacillus rhamnosus Genome sequencing
PRJNA1018213 | ENA
ProteomicsProteomic Analysis of the Differential Response of Pseudomonas aeruginosa and Staphylococcus aureus to Lacticaseibacillus rhamnosus Cell-Free Supernatant and Lactic Acid
This project investigates the proteomic response of Pseudomonas aeruginosa PAO1 and Staphylococcus aureus to postbiotic metabolites derived from Lacticaseibacillus rhamnosus. Bacterial cultures were exposed to sub-MIC concentrations of L. rhamnosus cell-free supernatant (CFS) or lactic acid (LA) for...
ORGANISM(S): Pseudomonas aeruginosa PAO1 Bacteria Staphylococcus aureus 
2026-01-05 | PXD069979 | Pride
Probiotics  postbiotics  antimicrobials  cell-free supernatants  l. rhamnosus  p. aeru-ginosa   s. aureus  proteomics. 
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