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MetabolomicsGlobal Analyses of Selective Insulin Resistance in Hepatocytes due to Palmitate Lipotoxicity
Obesity is tightly linked to hepatic steatosis and insulin resistance. One feature of this association is the paradox of selective insulin resistance: insulin fails to suppress hepatic gluconeogenesis but activates lipid synthesis in the liver. How lipid accumulation interferes selectively with some...
2018-04-26 | MTBLS582 | MetaboLights
ProteomicsProfiling of Native and Protease_Generated Protein Amino Termini from Formalin-Fixed, Paraffin-Embedded Tissues
Dysregulated proteolysis represents a hallmark of numerous diseases. In recent years, increasing number of studies has begun looking at the protein termini in hope to unveil the physiological and pathological functions of proteases in clinical research. However, the availability of cryopreserved tis...
ORGANISM(S): Mus musculus (Mouse) 
2016-04-25 | PXD002847 | Pride
Ffpe Protease Degradome Tails Proteolysis N-terminomics 
ProteomicsCharacterization of various cell lines from different ampullary cancer subtypes and cancer associated fibroblast-mediated responses
Introduction: Ampullary cancer is a relatively rare entity and usually treated by pancreatoduodenectomy followed by adjuvant therapy. The intestinal subtype is associated with markedly improved prognosis after resection. Only few cell lines are available for in vitro studies of ampullary cancer and ...
ORGANISM(S): Homo sapiens (Human) 
2016-03-14 | PXD002657 | Pride
Ampullary adenocarcinoma Cell invasion Differentiation Pancreatobiliary Cell proliferation Fibroblast Dysplastic Intestinal 
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