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ProteomicsProteomic analysis of skeletal muscle reveals estrogen as a key regulator of muscle signaling in women
Women’s aging is characterized by menopausal loss of ovarian function, which has been suggested as a contributing factor to aging-related muscle deterioration and predisposes to the metabolic dysfunctions. However, the underlying molecular mechanisms have remained unknown. To identify mechanisms, we...
ORGANISM(S): Homo sapiens (Human) 
2017-09-12 | PXD006446 | Pride
Human Estrogen Hdmse Aging Muscle Hormon replacement therapy 
ProteomicsIntegrative organelle-based functional proteomics in ARSACS-focus on bioenergetics and autophagy
Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is an inherited neurodegenerative disease characterized by early-onset spasticity in the lower limbs, axonal-demyelinating sensorimotor peripheral neuropathy, and cerebellar ataxia. Our understanding of the genetic basis, protein fun...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-12-20 | MSV000088592 | MassIVE
ProteomicsAccumulation of acylcarnitines and mitochondrial dysfunction characterize the loss of neonatal myocardial regeneration capacity
Myocardial regeneration capacity declines during the first week after birth and is linked to the adaptation to oxidative metabolism. Utilizing this regenerative window, we characterized the metabolic changes in myocardial injury in 1-day-old regeneration-competent and 7-day-old regeneration-compromi...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-02-04 | MSV000088783 | MassIVE
MetabolomicsGNPS - Accumulation of acylcarnitines and mitochondrial dysfunction characterize the loss of neonatal myocardial regeneration capacity
Myocardial regeneration capacity declines during the first week after birth and is linked to the adaptation to oxidative metabolism. Utilizing this regenerative window, we characterized the metabolic changes in myocardial injury in 1-day-old regeneration-competent and 7-day-old regeneration-compromi...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-02-04 | MSV000088783 | GNPS
ProteomicsLysosomal proteomics links disturbances in lipid homeostasis and sphingolipid metabolism to CLN5 disease.
The CLN5 disease (MIM: 256731) represents a rare late-infantile form of neuronal ceroid lipofuscinosis (NCL) caused by mutations in the CLN5 gene that encodes a CLN5 protein (CLN5p), whose physiological roles remain unanswered. No cure is currently available for CLN5 patients and the opportunities f...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2021-12-05 | MSV000088517 | MassIVE
OtherQuantitative interaction proteomics of neurodegenerative disease proteins.
Data from ProteomeXchange, PXD ID: PXD001942. File: 20130829_Orbi6_FaHo_SA_NN_SWEvsEV_Rep3_01.mzml. Published as part of Cell Rep. 2015 May 19;11(7):1134-46 . From the Abstract: {{i}} Several proteins have been linked to neurodegenerative disorders (NDDs), but their molecular function is not comple...
ORGANISM(S): Homo_sapiens_viruses, Human_female 
GPM32320018141 | GPMDB
Resource Reanalysis 
ProteomicsCLN5 involvement in mitochondrial dysfunction
CLN5 disease is a rare form of late-infantile neuronal ceroid lipofuscinosis (NCL) caused by mutations in the CLN5 gene that encodes a protein whose primary function and physiological roles remains unresolved. Emerging lines of evidence point to mitochondrial dysfunction in the onset and progression...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2020-02-01 | MSV000084880 | MassIVE
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