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ProteomicsA complex of the lipid transport ER proteins TMEM24 and C2CD2 with band 4.1 at cell-cell contacts.
Junctions between the ER and the plasma membrane (ER/PM junctions) are implicated in calcium homeostasis, non-vesicular lipid transfer and other cellular functions. Two ER proteins that function both as membrane tethers to the PM via a polybasic motif in their C-terminus and as phospholipid transpor...
ORGANISM(S): Homo sapiens (Human) 
2024-08-14 | PXD047112 | Pride
Syncam Lipid transfer Subsurface cisterns Smp domain C2cd2l 
ProteomicsMyelin-axon interface disruption uncovered by subcellular proteomics and imaging of Alzheimer’s human brain
Myelin ensheathment enables efficient axonal electrical conduction, metabolic support, and regulates neuronal plasticity. Myelin and axon disruptions are involved in Alzheimer’s disease (AD), however, the precise mechanisms of how myelin and axons are decoupled remain poorly understood. Using novel ...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2025-06-27 | PXD045861 | Pride
Lc-ms-ms Subcellular proteomics Alzheimer's disease Proximity labeling Human brain Myelin-axon interface 
TranscriptomicsA mechanism for the segregation of age in mammalian neural stem cells
Across life neural stem cells (NSCs) generate new neurons in the mammalian brain through asymmetric neurogenic and self-renewing cell divisions. However, the cellular mechanisms underlying NSC asymmetry remain unknown. Using fluorescence loss in photobleaching (FLIP) we here show that NSCs in vitro ...
ORGANISM(S): Mus musculus 
2015-09-22 | E-GEOD-61367 | biostudies-arrayexpress
TranscriptomicsmRNA-Seq and microRNA-Seq whole-transcriptome analysis of rhesus monkey ESC neural differentiation revealed the potential rosette neural stem cell regulators
Rosette neural stem cells (R-NSCs) represent early stage of neural development and possess full neural differentiation and regionalization capacities. R-NSCs are considered as stem cells of neural lineage and have important implications in study of neurogenesis and cell replacement therapy. However,...
ORGANISM(S): Macaca mulatta 
2014-07-03 | E-GEOD-53260 | biostudies-arrayexpress
Unknown[18F]Fluorocholine and [18F]Fluoroacetate PET as Imaging Biomarkers to Assess Phosphatidylcholine and Mitochondrial Metabolism in Preclinical Models of TSC and LAM.
Not available
S-EPMC6816044 | biostudies-literature
UnknownWhite matter brain age as a biomarker of cerebrovascular burden in the ageing brain.
Not available
S-EPMC12638326 | biostudies-literature
UnknownLong-term inhibition of mutant LRRK2 hyper-kinase activity reduced mouse brain α-synuclein oligomers without adverse effects.
Not available
S-EPMC9464237 | biostudies-literature
UnknownAssessment of brain age in posttraumatic stress disorder: Findings from the ENIGMA PTSD and brain age working groups.
Not available
S-EPMC8785613 | biostudies-literature
UnknownUpregulation of acid ceramidase contributes to tumor progression in tuberous sclerosis complex.
Not available
S-EPMC10243802 | biostudies-literature
UnknownThe longitudinal impact of screen media activities on brain function, architecture and mental health in early adolescence.
Not available
S-EPMC12206032 | biostudies-literature
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