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TranscriptomicsMolecular profiling of hypothalamic leucine-sensing neurons via PhosphoTRAP
To identify the molecular signature of leucine-activated neurons in the MBH, we adopted the PhosphoTRAP assay following parenchymal injection of leucine into the MBH. Neurons activated following MBH leucine injection (and expressing the neuronal activation marker cFos) co-express Ser240/244-phospho...
ORGANISM(S): Mus musculus 
2026-04-01 | E-MTAB-16665 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse small intestines
Rb and E2F are thought to play antagonistic roles in celll proliferation. However, this model is based mostly from in vitro cell culture systems. We used small intestines to test this model in vivo. We found that deletion of E2f1-3 in the small intestine of mice suppressed the ectopic expression o...
ORGANISM(S): Mus musculus 
2010-01-19 | E-GEOD-16454 | biostudies-arrayexpress
TranscriptomicsHIF-2alpha Knockdown in A498 (VHL-/-) ccRCC cells
HIF-2alpha is essential for (VHL-/-) ccRCC subcutaneous tumor growth in mice, and in tumor cell lines, its inhibition results in increased ROS accumulation, tumor cell death and responsiveness to radiation treatment. We have utilized transcriptional profiling to screen for putative HIF-2alpha target...
ORGANISM(S): Homo sapiens 
2009-08-27 | E-GEOD-16622 | biostudies-arrayexpress
TranscriptomicsClonal evolution and devolution following chemotherapy in adult acute myelogenous leukemia
The frequent occurrence of persistent or relapsed disease following induction chemotherapy in AML necessitates a better understanding of the clonal relationship of AML in various disease phases. In this study, we employed SNP 6.0 array-based genomic profiling of acquired copy number aberrations (aCN...
ORGANISM(S): Homo sapiens 
2013-02-12 | E-GEOD-41646 | biostudies-arrayexpress
TranscriptomicsmiR-122 as a Regulator of Mitochondrial Metabolic Gene Network in Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is the leading cause of cancer-related deaths worldwide, reflecting the need for a better understanding of hepatocarcinogenesis. In this study, we examined the genome-wide expression profiles of both miRNAs and mRNAs from paired tumor and adjacent non-tumor tissues fro...
ORGANISM(S): Homo sapiens 
2010-06-09 | E-GEOD-22058 | biostudies-arrayexpress
TranscriptomicsAscorbic acid depletion and scorbutic extracellular matrix in mice deficient in endoplasmic reticulum thiol oxidases
Endoplasmic reticulum (ER) thiol oxidases initiate a disulfide relay to oxidatively-fold secreted proteins. We found that combined loss-of-function mutations in genes encoding the ER thiol oxidases ERO1alpha, ERO1beta and PRDX4, compromised the extracellular matrix in mice and interfered with the in...
ORGANISM(S): Mus musculus 
2012-09-15 | E-GEOD-39492 | biostudies-arrayexpress
ProteomicsProtein Turnover Rates in Normal and Hypertrophy Mouse Hearts
This dataset contains the in vivo turnover rate information of ~3,000 proteins from the mouse heart. Data from six common laboratory mouse strains with differential responses to isoproterenol are included
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2017-11-08 | MSV000081697 | MassIVE
TranscriptomicsExpression data from skeletal muscle biopsies of healthy adults
Healthy adults with serum insulin like growth factor -1 (IGF-I) levels at the lowest quartile of normal ranges have increased fat metabolism and reduced glucose utlisation compared with those in the highest quartile during fasting We used gene expression in skeletal muscle to explore metabolism duri...
ORGANISM(S): Homo sapiens 
2013-11-15 | E-GEOD-49297 | biostudies-arrayexpress
ProteomicsM.musculus - Heart, NSAF (Lauetal,scidata2016)
abundance based on NSAF, Interaction consistency score: 38.1, Coverage: 31
ORGANISM(S): 10090 
2016-00-00 | 1153777653 | PAXDB
TranscriptomicsExpression of CD39 and CD45RO on CD4+CD25hi T cells identifies human naïve (G3) and effector Treg (G2), and distinguishes them from activated non-Treg cells (Tresp).
Human responder T-cells (Tresp) and 2 lineages of regulatory T cells (Tregs), namely G2 and G3, were isolated by flow sorting based on their immunoreacitivities against specific cell surface markers and their gene expression profiles were interrogated using Affymetrix Exon 1.0 ST Arrays Comparison o...
ORGANISM(S): Homo sapiens 
2013-10-01 | E-GEOD-47667 | biostudies-arrayexpress
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