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TranscriptomicsCompensatory IKKa activation of classical NF-kB signaling during IKKb inhibition
A subtype of diffuse large B-cell lymphoma (DLBCL), termed activated B-cell-like (ABC) DLBCL, depends on constitutive NF-kB pathway signaling for survival. Small molecule inhibitors of IkB kinase b (IKKb), a key regulator of the NF-kB pathway, kill ABC DLBCL cells and hold promise for the treatment ...
ORGANISM(S): Homo sapiens 
2009-06-01 | E-GEOD-11902 | biostudies-arrayexpress
TranscriptomicsCooperative Signaling Through the STAT3 and NF-kB Pathways in Subtypes of DLBCL
The activated B cell-like (ABC) subgroup of diffuse large B cell lymphoma (DLBCL) is characterized by constitutive activation of the NF-êB pathway. Here we show that the NF- êB pathway induces the expression of the cytokines IL-6 and IL-10 in ABC DLBCL cell lines, which also have high levels of to...
ORGANISM(S): Homo sapiens 
2010-05-27 | E-GEOD-10009 | biostudies-arrayexpress
TranscriptomicsRibosomal protein S3: a functional component of NF-kB p65 binding complexes
To explore the effects on the NF-kB transcriptome after knockdown of RPS3 in stimulated T cells, we performed microarray assays comparing RPS3-silenced versus NS-treated samples on the same chip. p65-silenced versus NS-treated samples were used as a control. Keywords: time series design Jurkat cells...
ORGANISM(S): Homo sapiens 
2010-05-26 | E-GEOD-7231 | biostudies-arrayexpress
TranscriptomicsEvidence that TSC2 acts as a transcription factor and binds to and represses the promoter of Epiregulin
In order to identify the genes regulated by TSC2, gene expression profiling of two clones stably overexpressing TSC2 was performed. The gene expression profiles of two stable transfectant clones overexpressing the full-length TSC2 in KB cells were compared with the gene expression profile of a vecto...
ORGANISM(S): Homo sapiens 
2013-11-05 | E-GEOD-52061 | biostudies-arrayexpress
TranscriptomicsTranscription dependent dynamic supercoiling in Raji human B cells in vivo
Transcription has the capacity to modify mechanically DNA topology, DNA structure, and nucleosome arrangement. Resulting from ongoing transcription, these modifications in turn, may provide instant feedback to the transcription machinery. To substantiate the connection between transcription and DNA ...
ORGANISM(S): Homo sapiens 
2013-02-16 | E-GEOD-43751 | biostudies-arrayexpress
MetabolomicsTargeting the SREBP-dependent lipidomic reprogramming by virus infection for broad-spectrum therapeutic intervention
Viruses are obligate intracellular parasites that exploit the host metabolic machineries to meet their extraordinary biosynthetic demands. Integrative transcriptomic and lipidomic profiling confirmed that Middle East respiratory syndrome coronavirus (MERS-CoV) infection reprograms the host lipid met...
2018-11-26 | MTBLS762 | MetaboLights
TranscriptomicsProtein profiling reveals five principal chromatin types in Drosophila cells
The local protein composition of chromatin is important for the regulation of transcription and other functions. By integrative analysis of genome-wide binding maps of 53 broadly selected chromatin components in Drosophila cells, we show that the genome is segmented into five principal chromatin typ...
ORGANISM(S): Drosophila melanogaster 
2010-10-01 | E-GEOD-22069 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human osteoblast transcriptome in resting and induced primary cells
Osteoblasts are key players in bone remodeling. The accessibility of human primary osteoblast-like cells (HOb) from bone explants render them a lucrative model for studying molecular physiology of bone turnover, discovery of novel anabolic therapeutics and mesenchymal cell biology in general. Relati...
ORGANISM(S): Homo sapiens 
2008-06-11 | E-GEOD-10311 | biostudies-arrayexpress
TranscriptomicsSodium arsenite induced DNA methylation changes in A549 human epithelial lung carcinoma cells
Arsenic is methylated during its metabolism, thereby depleting the intracellular methyl donor S-adenosyl-methionine, which may lead to disturbances in DNA methylation patterns Cells were exposed to sodium arsenite (NaAsO2, Sigma) at concentrations of 0.08 M-BM-5M, 0.4 M-BM-5M and 2 M-BM-5M for 1, 2 ...
ORGANISM(S): Homo sapiens 
2014-09-17 | E-GEOD-44173 | biostudies-arrayexpress
UnknownGlobal analysis of the impact of environmental perturbation on cis-regulation of gene expression.
Not available
S-EPMC3024267 | biostudies-literature
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