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ProteomicsGlobal Chromatin Profiling Dataset of Chemical Perturbations in Multiple Biological Backgrounds
The Library of Integrated Network-based Cellular Signatures (LINCS) Program aims to create a network-based understanding of biology by cataloging changes in gene expression and other cellular processes that occur when cells are exposed to a variety of perturbing agents. The goal of this project is t...
ORGANISM(S): Homo Sapiens 
2022-03-02 | PXD017459 | panorama
ProteomicsPhospho-proteomic Profiling Dataset of Chemical Perturbations in Multiple Biological Backgrounds
The Library of Integrated Network-based Cellular Signatures (LINCS) Program aims to create a network-based understanding of biology by cataloging changes in gene expression and other cellular processes that occur when cells are exposed to a variety of perturbing agents. The goal of this project is t...
ORGANISM(S): Homo Sapiens 
2022-03-02 | PXD017458 | panorama
TranscriptomicsCollier/OLF/EBF-dependent transcriptional dynamics control muscle specification from cardiopharyngeal progenitors
In vertebrates, pluripotent pharyngeal mesoderm progenitors produce the cardiac precursors of the second heart field as well as the branchiomeric head muscles and associated stem cells. However, the cellular and molecular mechanisms underlying the transition from multipotent progenitors to distinct ...
ORGANISM(S): Ciona intestinalis 
2014-07-17 | E-GEOD-54746 | biostudies-arrayexpress
TranscriptomicsBowel expression profiles of infants with gastrointestinal conditions
We have employed whole genome microarray expression profiling to identify genes differentially expressed in neonatal bowel tissues of different gastrointestinal conditions. Bowel tissues were collected from infants who underwent surgery treatment for necrotising enterocolitis (NEC) and spontaneous i...
ORGANISM(S): Homo sapiens 
2014-01-21 | E-GEOD-46619 | biostudies-arrayexpress
TranscriptomicsPGN induced transcriptional changes in human neonatal neutrophils
We have employed whole genome microarray expression profiling to identify genes differentially expressed in cord blood purified neutrophils after a short-term exposure to peptidoglycan (PGN). PGN induced gene expressions of neonatal neutrophils were measured at 4 hours. Three biological replicates w...
ORGANISM(S): Homo sapiens 
2013-09-04 | E-GEOD-40636 | biostudies-arrayexpress
TranscriptomicsBowel miRNA expression profiles of infants with gastrointestinal conditions
We have employed miRNA microarray expression profiling to identify miRNA differentially expressed in neonatal bowel tissues with different gastrointestinal conditions. Bowel tissues were collected from infants who underwent surgery treatment for necrotizing enterocolitis (NEC), spontaneous intestina...
ORGANISM(S): Homo sapiens 
2015-08-24 | E-GEOD-68054 | biostudies-arrayexpress
TranscriptomicsApplication of a clinical assay for staging and prognosis of prostate cancer diagnosed in needle core biopsy specimens
Molecular and genomic analysis of microscopic quantities of tumor from formalin-fixed and paraffin-embedded (FFPE) biopsies has many unique challenges. Here we evaluated the feasibility of obtaining transcriptome-wide RNA expression to measure prognostic classifiers from diagnostic prostate needle c...
ORGANISM(S): Homo sapiens 
2016-03-09 | E-GEOD-72220 | biostudies-arrayexpress
TranscriptomicsRNA-seq of Zbtb20-expressing Tregs against activated (CD62Llo) and naive (CD62Lhi) Tregs that do not express Zbtb20
The objective of this study was to determine if a subset of regulatory T cells (Tregs) expressing the transcription factor, Zbtb20, played a unique role in the function of the immune system. Genetic reporter mice were used to isolate Zbtb20-expressing Tregs as well as activated (CD62Llo) and naive (...
ORGANISM(S): Mus musculus 
2022-02-25 | E-MTAB-11442 | biostudies-arrayexpress
MetabolomicsSARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals
Viruses manipulate cellular metabolism and macromolecule recycling processes like autophagy. Dysregulated metabolism might lead to excessive inflammatory and autoimmune responses as observed in severe and long COVID-19 patients. Here we show that SARS-CoV-2 modulates cellular metabolism and reduces ...
2021-06-11 | MTBLS2840 | MetaboLights
TranscriptomicsMicroarray-based CGH in human cancer cell lines
This series represents the data set from the paper Assembly of microarrays for genome-wide measurement of DNA copy number appearing in Nat Genet 2001 Nov;29(3):263-4 and it's web supplement. Specimen procurement, labeling, hybridization and imaging protocols from Nat Genet 2001 Nov;29(3):263-...
ORGANISM(S): Homo sapiens 
2010-06-05 | E-GEOD-16 | biostudies-arrayexpress
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