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TranscriptomicsDeleterious assembly of the lamin A/C mutant p.S143P causes ER stress in familial dilated cardiomyopathy
Mutation of the LMNA gene, encoding nuclear lamin A and lamin C (hereafter lamin A/C), is a common cause of familial dilated cardiomyopathy (DCM). Among Finnish DCM patients, the founder mutation c.427T>C (p.S143P) is the most frequently reported genetic variant. Here, we show that p.S143P lamin A/C...
ORGANISM(S): Homo sapiens 
2016-06-10 | E-GEOD-82290 | biostudies-arrayexpress
TranscriptomicsLamin binding profiles in the ENCODE regions
A systems understanding of nuclear organization and events is critical for determining how cells divide, differentiate and respond to stimuli and for identifying the causes of diseases. Chromatin remodeling complexes such as SWI/SNF have been implicated in a wide variety of cellular processes includ...
ORGANISM(S): Homo sapiens 
2011-01-10 | E-GEOD-24382 | biostudies-arrayexpress
ProteomicsLamin A dimer and tetramer cross-links help explain disease mutations and polymer plasticity
Lamins are intermediate filament proteins responsible for nuclear mechanical integrity. Though linked to multiple heritable diseases, lamin structure and that of other intermediate filaments remains elusive. We employed cross-linking mass spectrometry to gain structural insights into lamin A dimer a...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2019-07-12 | PXD008337 | Pride
Silac Cross-link mass spectrometry Em Lamin a 
GenomicsCorrelated alterations in genome organization, histone methylation, and DNA-lamina interactions in Hutchinson-Gilford progeria syndrome (ChIP-seq)
Hutchinson-Gilford progeria syndrome (HGPS) is a premature aging disease that is frequently caused by a de novo point mutation at position 1824 in LMNA. This mutation activates a cryptic splice donor site in exon 11, and leads to an in-frame deletion within the prelamin A mRNA and the production of ...
ORGANISM(S): Homo sapiens 
2012-10-30 | E-GEOD-41757 | biostudies-arrayexpress
GenomicsRedistribution of the Lamin B1 genomic binding profile affects spatial rearrangement of heterochromatic domains and gene expression during senescence
Senescence is a stress responsive form of stable cell cycle exit. Senescent cells have a distinct gene expression profile, which is often accompanied by the spatial redistribution of heterochromatin into senescence-associated heterochromatic foci (SAHFs). Studying a key component of the nuclear lami...
ORGANISM(S): Homo sapiens 
2013-08-22 | E-GEOD-49341 | biostudies-arrayexpress
ProteomicsLow and High Lamin A/C Adipose-Derived Stem Cells
Proteomics for sorted low vs. high 20% of lamin A/C-expressing primary, human, adipose-derived stem cells compared to an unsorted population
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-05-28 | MSV000087538 | MassIVE
ProteomicsProteasome dysfunction leads to enhanced autophagy mediated degradation of mutant lamin A/C
Lamin A/C are nuclear intermediate filament proteins that form a proteinaceous meshwork called lamina beneath the inner nuclear membrane. Mutations in the LMNA gene encoding lamin A/C cause a heterogenous group of inherited degenerative diseases known as laminopathies. Previous studies have revealed...
ORGANISM(S): Homo sapiens (Human) 
2022-09-07 | PXD033937 | Pride
Lamin a/c Autophagy Ubiquitin-proteasome-system Disease mutations Degradation Ubiquitin 
TranscriptomicsLamin A/C Is Required For ChAT-Dependent Neuroblastoma Differentiation: a microarray gene expression study
The mouse neuroblastoma N18TG2 clone is unable to differentiate and defective for the enzymes of the biosynthesis of neurotransmitters. The forced expression of choline acetyltransferase (ChAT) in these cells results in the synthesis and release of acetylcholine (Ach) and hence in the expression of ...
ORGANISM(S): Mus musculus 
2017-04-18 | E-GEOD-73591 | biostudies-arrayexpress
GenomicsMechanical control of MSC adipogenesis does not require Lamin A/C
Mechanical control of MSC adipogenesis does not require Lamin A/C
PRJNA659991 | ENA
GenomicsLamin A/C promotes DNA base excision repair (mouse arrays)
Lamin A/C promotes DNA base excision repair (mouse arrays)
PRJNA492926 | ENA
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