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ProteomicsNuclear lamin A/C phosphorylation by loss of Androgen Receptor is a global determinant of cancer-associated fibroblast activation
Alterations of nuclear structure and function, and associated impact on gene transcription, are a hallmark of cancer cells. Little is known of these alterations in Cancer-Associated Fibroblasts (CAFs), a key component of the tumor stroma. Here we show that loss of androgen receptor (AR), which trigg...
ORGANISM(S): Homo sapiens (Human) 
2024-08-12 | PXD042059 | Pride
Human Cancer-associated fibroblasts Androgen receptor 
ProteomicsHuman lamin B1: stress-induced phosphorylation
This is a small scale study of the phosphorylation state of human lamin B1 immunoprecipitated from control cells or cells treated with methyl methane sulphonate (MMS, acting as a DNA damage stressor agent)
ORGANISM(S): Homo sapiens (Human) 
2017-05-30 | PXD006459 | Pride
Human Post translational modification Nuclear envelope Lamin 
ProteomicsSETD2 N-terminus mediates interaction with Lamins
Histone-Lysine N-methyltransferase SETD2 is an evolutionarily conserved histone methyltransferase that associates with RNA Polymerase II (RNAPII) and catalyzes trimethylation of histone H3 lysine 36 (H3K36me3) in transcribed regions. Interestingly, SETD2 is frequently mutated in cancers. Clear cell ...
ORGANISM(S): Homo sapiens (Human) 
2025-06-04 | PXD040771 | Pride
Setd2 Cdk1 Mitosis Lamin 
GenomicsNuclear lamin A/C phosphorylation by loss of Androgen Receptor is a global determinant of cancer-associated fibroblast activation
Nuclear lamin A/C phosphorylation by loss of Androgen Receptor is a global determinant of cancer-associated fibroblast activation
PRJNA1107166 | ENA
GenomicsNuclear lamin A/C phosphorylation by loss of Androgen Receptor is a global determinant of cancer-associated fibroblast activation [Affymetrix]
Nuclear lamin A/C phosphorylation by loss of Androgen Receptor is a global determinant of cancer-associated fibroblast activation [Affymetrix]
PRJNA975433 | ENA
GenomicsNuclear lamin A/C phosphorylation by loss of Androgen Receptor is a global determinant of cancer-associated fibroblast activation [ChIP-Seq2]
Nuclear lamin A/C phosphorylation by loss of Androgen Receptor is a global determinant of cancer-associated fibroblast activation [ChIP-Seq2]
PRJNA961664 | ENA
GenomicsNuclear lamin A/C phosphorylation by loss of Androgen Receptor is a global determinant of cancer-associated fibroblast activation [ChIP-Seq]
Nuclear lamin A/C phosphorylation by loss of Androgen Receptor is a global determinant of cancer-associated fibroblast activation [ChIP-Seq]
PRJNA1141461 | ENA
GenomicsNuclear lamin A/C phosphorylation by loss of Androgen Receptor is a global determinant of cancer-associated fibroblast activation [ATAC-Seq]
Nuclear lamin A/C phosphorylation by loss of Androgen Receptor is a global determinant of cancer-associated fibroblast activation [ATAC-Seq]
PRJNA961103 | ENA
ProteomicsLamin A/C-EZH2 interaction in breast cancer cells
Epithelial-to-mesenchymal transition (EMT) is a developmentally conserved cell biological program adopted by cancer cells to metastasize to different organs. In this process, compact, cobblestone-shaped epithelial cells transform into more slender-shaped mesenchymal cells. Throughout metastasis, cel...
ORGANISM(S): Homo sapiens (Human) 
2025-12-23 | PXD060831 | Pride
Breast cancer Emt Lamin a/c Ezh2 
GenomicsMechanical control of MSC adipogenesis does not require Lamin A/C
Mechanical control of MSC adipogenesis does not require Lamin A/C
PRJNA659991 | ENA
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