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MetabolomicsTargeted GC-MS of SETD2 isogenic cell lines
Not available
ORGANISM(S): Homo sapiens 
ST001086 | MetabolomicsWorkbench
ProteomicsSETD2 N-terminus mediates interaction with Lamins
Histone-Lysine N-methyltransferase SETD2 is an evolutionarily conserved histone methyltransferase that associates with RNA Polymerase II (RNAPII) and catalyzes trimethylation of histone H3 lysine 36 (H3K36me3) in transcribed regions. Interestingly, SETD2 is frequently mutated in cancers. Clear cell ...
ORGANISM(S): Homo sapiens (Human) 
2025-06-04 | PXD040771 | Pride
Setd2 Cdk1 Mitosis Lamin 
TranscriptomicsComparison of gene expression pattern between Wild-type and Setd2 knockout mESCs [Affymetrix]
SETD2/HYPB has been known as a histone H3K36 specific methyltransferase. However, its roles in physiology such as development and cellular function remain unclear. In this study, using mESCs as cellular model, we show that Setd2 mainly regulates differentiation of murine embryonic stem cells (mESCs)...
ORGANISM(S): Mus musculus 
2014-10-14 | E-GEOD-54931 | biostudies-arrayexpress
TranscriptomicsQuantitative Analysis of Wild Type(wt) and Setd2 knockout(ko) mESCs Transcriptomes [RNA-Seq]
Purpose: This study aimed at exploring the deregulated genes in setd2 knockout mESCs compared with wt, more particularly to find the mechanism controlled by setd2,which was required for endoderm differentiation. Methods: Setd2 wt and ko mESCs were generated by deep sequencing, using Illumina GAIIx. ...
ORGANISM(S): Mus musculus 
2014-10-14 | E-GEOD-54932 | biostudies-arrayexpress
ProteomicsMolecular mechanism of co-transcriptional H3K36 methylation by SETD2
H3K36me3 is a hallmark of actively and recently transcribed genes and contributes to cellular memory and identity. The deposition of H3K36me3 occurs co-transcriptionally when the methyltransferase SETD2 associates with RNA polymerase II. Using electron microscopy assisted by protein-protein crosslin...
ORGANISM(S): Homo sapiens (Human) Sus scrofa domesticus (domestic pig) 
2025-09-18 | PXD067197 | Pride
Histone chaperone fact Cxms Setd2 Rna polymerase ii Transcription elongation 
TranscriptomicsRNA sequencing of SETD2 isogenic renal cell carcinoma cell lines
RNA sequencing of SETD2 isogenic renal cell carcinoma cell lines. Examination of RNA expression in SETD2 isogenic cell lines
ORGANISM(S): Homo sapiens 
2015-06-17 | E-GEOD-66879 | biostudies-arrayexpress
GenomicsSetd2 knockdown.
Setd2 knockdown.
PRJNA612891 | ENA
TranscriptomicsGene expression pattern between Wild-type and Setd2 knockout mESCs
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2014-10-14 | E-GEOD-54933 | biostudies-arrayexpress
ProteomicsProteomics analysis on SETD2 loss induced ccRCC formation
Patients with polycystic kidney disease (PKD) encounter a high risk of clear cell renal cell carcinoma (ccRCC), a malignant tumor with dysregulated lipid metabolism. SET domain–containing 2 (SETD2) has been identified as an important tumor suppressor gene in ccRCC. However, the role of SETD2 in tumo...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-31 | PXD038966 | Pride
Polycystic kidney disease (pkd) Set domain–containing 2 (setd2) Clear cell renal cell carcinoma (ccrcc) 
GenomicsSplicing enhances recruitment of methyltransferase HYPB/Setd2 and methylation of histone H3 lysine 36
Several lines of recent evidence support a role for chromatin in splicing regulation. Here we show that splicing can also contribute to histone modification, which implies a bidirectional communication between epigenetics and RNA processing. Genome-wide analysis of histone methylation in human cell ...
ORGANISM(S): Homo sapiens 
2011-07-25 | E-GEOD-30902 | biostudies-arrayexpress
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