Sort   by:  
 Page size 
GenomicsRedistribution of the Lamin B1 genomic binding profile affects spatial rearrangement of heterochromatic domains and gene expression during senescence
Senescence is a stress responsive form of stable cell cycle exit. Senescent cells have a distinct gene expression profile, which is often accompanied by the spatial redistribution of heterochromatin into senescence-associated heterochromatic foci (SAHFs). Studying a key component of the nuclear lami...
ORGANISM(S): Homo sapiens 
2013-08-22 | E-GEOD-49341 | biostudies-arrayexpress
UnknownLamin B2 Modulates Nucleolar Morphology, Dynamics, and Function.
Not available
S-EPMC5705821 | biostudies-literature
UnknownReciprocal knock-in mice to investigate the functional redundancy of lamin B1 and lamin B2.
Not available
S-EPMC4019497 | biostudies-literature
UnknownLamin B1 and lamin B2 are long-lived proteins with distinct functions in retinal development.
Not available
S-EPMC4907726 | biostudies-literature
TranscriptomicsStochastic genome-nuclear lamina interactions: Modulating roles of Lamin A and BAF
The nuclear lamina (NL) is a filamentous layer lining the inner-nuclear-membrane (INM) that aids in the organization of the genome in large domains of low transcriptional activity. Recently, it was shown that the single-cell genome-NL interactions are much more dynamic than previously anticipated, w...
ORGANISM(S): Homo sapiens 
2014-02-15 | E-GEOD-55066 | biostudies-arrayexpress
UnknownLamin B2 prevents chromosome instability by ensuring proper mitotic chromosome segregation.
Not available
S-EPMC4038388 | biostudies-literature
TranscriptomicsGene expression changes upon Lamin A and Lamin B2 depletion in a diploid colorectal cancer cell line - DLD1
Small interfering RNA (siRNA) mediated depletion of Lamin A/C and Lamin B2 was performed in a diploid colorectal cancer cell line - DLD1 with an aim to identify transcription deregulation across the genome.
ORGANISM(S): Homo sapiens 
2016-09-24 | GSE73269 | GEO
UnknownChromosomal aneuploidies induced upon Lamin B2 depletion are mislocalized in the interphase nucleus.
Not available
S-EPMC5371638 | biostudies-literature
GenomicsDistinct structural and functional heterochromatin partitioning of lamin B1 and lamin B2 revealed using genome-wide Nicking Enzyme Epitope targeted DNA sequencing.
Gene expression is regulated by chromatin DNA methylation and other features, including histone post-translational modifications (PTMs), chromatin remodelers, and transcription factor occupancy. A complete understanding of gene regulation will require the mapping of these chromatin features in small...
ORGANISM(S): Homo sapiens 
2025-01-16 | GSE261834 | GEO
UnknownPerinuclear Lamin A and Nucleoplasmic Lamin B2 Characterize Two Types of Hippocampal Neurons through Alzheimer's Disease Progression.
Not available
S-EPMC7084765 | biostudies-literature
Sort   by:  
 Page size