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GenomicsA Surveillance System of Active Enhancers by a RACK7-histone Demethylase Complex (ChIP-Seq I)
Primed enhancers are marked by histone H3K4 mono-methylation (H3K4me1), and the conversion to active enhancers involves acetylation of histone H3K27 (H3K27Ac). However, whether active enhancers are regulated remains unclear. Here we report a biochemical complex consisting of a potential chromatin re...
ORGANISM(S): Homo sapiens 
2016-04-07 | E-GEOD-71323 | biostudies-arrayexpress
GenomicsA Surveillance System of Active Enhancers by a RACK7-histone Demethylase Complex (ChIP-Seq II)
Primed enhancers are marked by histone H3K4 mono-methylation (H3K4me1), and the conversion to active enhancers involves acetylation of histone H3K27 (H3K27Ac). However, whether active enhancers are regulated remains unclear. Here we report a biochemical complex consisting of a potential chromatin re...
ORGANISM(S): Mus musculus 
2016-04-07 | E-GEOD-76637 | biostudies-arrayexpress
TranscriptomicsTranscriptome Comparison of Cabernet Sauvignon Grape Berries from Two Regions with Distinct Climate
To obtain an interpretation from the view of transcriptome on distinct metabolite accumulation between ecologically different regions in China, next-generation sequencing technology was performed on E-L 31, 35 and 38 stages of Cabernet Sauvignon grape berries from Changli (CL, eastern) and Gaotai (G...
ORGANISM(S): Vitis vinifera 
2014-11-21 | E-GEOD-63512 | biostudies-arrayexpress
TranscriptomicsExpression data from Saccharomyces cerevisiae temperature-sensitive strains specific for SCF core components (Skp1, Cullin (Cdc53), E2 enzyme (Cdc34)) and the F-box protein Cdc4.
The target of rapamycin (TOR) plays a central role in eukaryotic cell growth control. With prevalent hyper-activation of the mTOR pathway in human cancers, novel strategies to enhance TOR pathway inhibition are highly desirable. We used a yeast-based high-throughput chemical genetic screen to identi...
ORGANISM(S): Saccharomyces cerevisiae 
2011-06-30 | E-GEOD-22271 | biostudies-arrayexpress
GenomicsGenome-Wide Mapping of 5-mC and 5-hmC in severely Preeclamptic Placentas.
Preeclampsia (PE) is a major contributor of maternal mortality with uncertain etiology. Recent studies suggested that epigenetic modifications, including DNA methylation, play a vital role in the development of PE. In this study, we have mapped genome-wide distribution of 5-methylcytosin (5-mC) and ...
ORGANISM(S): Homo sapiens 
2014-12-13 | E-GEOD-63743 | biostudies-arrayexpress
ProteomicsSerum proteomic analysis identifies SAA1, FGA，SAP and CETP as new biomarkers for Eosinophilic granulomatosis with polyangiitis
Our findings suggest that DIA combined with PRM mass spectrometric method was effective in identifying and validating the candidate biomarkers for several diseases including EGPA diagnosis. We have discovered and validated three new potentially serum biomarkers FGA, SAP and CETP for discriminating E...
ORGANISM(S): Homo Sapiens 
2022-02-15 | PXD029759 |
UnknownOocyte-Specific Knockout of Histone Lysine Demethylase KDM2a Compromises Fertility by Blocking the Development of Follicles and Oocytes.
Not available
S-EPMC9570323 | biostudies-literature
ProteomicsSerum proteomics identify biomarkers associated with the pathogenesis of idiopathic pulmonary fibrosis
This serum proteomic profile provides rigorous evidence that enables understanding of the heterogeneity of IPF and protein alterations that could help in its diagnosis and treatment decisions.
ORGANISM(S): Homo Sapiens 
PXD052329 |
UnknownN-glycosylation stabilizes MerTK and promotes hepatocellular carcinoma tumor growth.
Not available
S-EPMC9214875 | biostudies-literature
GenomicsThe mental retardation gene PHF8 mediates histone H4K20/H3K9 demethylation and regulates zebrafish brain apoptosis and craniofacial development: ChIP-Seq analysis
PHF8 (PHD Finger 8) mutations have been found in patients with X-linked mental retardation (XLMR) and craniofacial deformities. Here we identify PHF8 as the first enzyme that mediates demethylation of mono-methylated histone H4 lysine (K) 20 (H4K20me1), with additional activities towards H3K9me2/1 a...
ORGANISM(S): Homo sapiens 
2010-07-14 | E-GEOD-21108 | biostudies-arrayexpress
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