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ProteomicsComparative gene and protein expression profile of olfactory ensheathing cells from olfactory bulb and olfactory mucosa
Olfactory ensheathing cells are one of the few central nervous system regenerative cells discovered so far. It is characterized by its lifelong nerve regeneration function, and it can also release a variety of neurotrophic factors and neural adhesion molecules. It is considered to be the glial cell ...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-16 | PXD024046 | Pride
Olfactory ensheathing cells (oecs)  olfactory bulb (ob)  olfactory mucosa (om)  gene  protein  gene ontology (go)  kyoto encyclopedia of genes and genomes (kegg)  molecular function  cellular component  biological process 
MetabolomicsMetabolomic Profiling of Non-target Metabolites in Streptomyces sp. LZZY-S40
This study aimed to characterize the non-targeted metabolite profile of Streptomyces sp. LZZY-S40 to explore its potential for producing bioactive secondary metabolites. The strain LZZY-S40 was cultivated on ISP 3 agar plates at 28°C for 7 days. Spores were harvested and inoculated into 250 mL Erlen...
2026-03-29 | MTBLS14181 | MetaboLights
ProteomicsExosomes from mesenchymal stromal cells reduce murine colonic inflammation via a macrophage-dependent mechanism
Conventional treatments for inflammatory bowel disease (IBD) have multiple potential side effects. Therefore, alternative treatments are desperately needed. In the present study, we proposed a new therapeutic tool for the treatment of IBD in murine pre-clinical models by using MSC-Exos. We demonstra...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2020-05-27 | PXD015386 | Pride
Inflammatory bowel disease Exosomes Macrophages Mesenchymal stromal cells 
ProteomicsComparative phosphoproteomics of classical bordetellae elucidates the role of serine, threonine and tyrosine phosphorylation in Bordetella biology and virulence
This study characterised the Ser/Thr/Tyr phosphoproteome of classical Bordetella species and examined its role in Bordetella biology and virulence. This study found 70 unique phosphorylated proteins in the classical bordetellae group with a high degree of conservation observed and phosphorylation wa...
ORGANISM(S): Bordetella pertussis Bordetella parapertussis 12822 Bordetella bronchiseptica RB50 
2021-03-26 | PXD020866 | Pride
Virulence Phosphoproteome Whooping cough Fusion lumos Bordetella pertussis Bvga Bordetella parapertussis Bordetella bronchiseptica 
TranscriptomicsInfluence of BrpA on critical virulence attributes of Streptococcus mutans
Streptococcus mutans, the primary etiological agent of human dental caries, has developed multiple mechanisms to colonize and form biofilms on the tooth surface. The brpA gene codes for a predicted surface-associated protein with apparent roles in biofilm formation, autolysis, and cell division. In ...
ORGANISM(S): Streptococcus mutans 
2008-08-30 | E-GEOD-11773 | biostudies-arrayexpress
TranscriptomicsProfiling circulating microRNA expression in a mouse model of nerve allotransplantation (part 2)
Background. The lack of noninvasive biomarkers of rejection remains a challenge in the accurate monitoring of deeply buried nerve allografts and precludes optimization of therapeutic intervention. This study aimed to establish the expression profile of circulating microRNAs (miRNAs) during nerve all...
ORGANISM(S): Mus musculus 
2014-07-01 | E-GEOD-48971 | biostudies-arrayexpress
ProteomicsTargeting phosphorylation of 17β-hydroxysteroid dehydrogenase 13 at serine 33 to treat nonalcoholic steatohepatitis
17β-hydroxysteroid dehydrogenase-13 (17β-HSD13) is a liver-rich lipid droplet associated protein, encoding by gene HSD17B13, that acted as an important regulator of hepatic lipid metabolism. Increased expression of 17β-HSD13 promotes hepatic lipid accumulation in rodents, and a common loss-of-functi...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD037262 | Pride
Human Lc-msms 17β-hsd13 protein gel band 293t cell 
TranscriptomicsProfiling circulating microRNA expression in a mouse model of nerve allotransplantation (part 1)
Background. The lack of noninvasive biomarkers of rejection remains a challenge in the accurate monitoring of deeply buried nerve allografts and precludes optimization of therapeutic intervention. This study aimed to establish the expression profile of circulating microRNAs (miRNAs) during nerve all...
ORGANISM(S): Mus musculus 
2014-07-01 | E-GEOD-48969 | biostudies-arrayexpress
TranscriptomicsSperm but not oocyte DNA methylome is inherited by zebrafish early embyros
5-methylcytosine is a major epigenetic modification sometimes called "the fifth nucleotide". However, our knowledge of how offspring inherit the DNA methylome from parents is limited. We generated nine single-base resolution DNA methylomes including zebrafish gametes and early embryos. The...
ORGANISM(S): Danio rerio 
2013-05-20 | E-GEOD-44075 | biostudies-arrayexpress
TranscriptomicsThe two-component system ChrSA is crucial for heme tolerance and interferes with HrrSA in heme-dependent gene regulation in Corynebacterium glutamicum
We recently showed that the two-component system (TCS) HrrSA plays a central role in the control of heme homeostasis in the Gram-positive soil bacterium Corynebacterium glutamicum. Here, we characterized the function of another TCS of this organism, ChrSA, which exhibits significant sequence similar...
ORGANISM(S): Corynebacterium glutamicum ATCC 13032 
2012-10-31 | E-GEOD-37327 | biostudies-arrayexpress
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