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ProteomicsProteomic Profiling of Non-Muscle Invasive Bladder Cancer Reveals Stage-Specific Molecular Signatures and Prognostic Biomarkers
Non-Muscle Invasive Bladder Cancer (NMIBC) includes High-Grade (HG) and Low-Grade (LG) variants, classified by aggressiveness, recurrence risk, and tumor stage—either non-invasive (pTa) or invading the lamina propria (pT1). Cystoscopy is the diagnostic gold standard, with no less invasive alternativ...
ORGANISM(S): Homo sapiens (Human) 
2026-01-05 | PXD069436 | Pride
Nmibc  tumor stage  proteomics  prognostic markers  pdc6i 
ProteomicsCharacterization of extracellular vesicles in human seminal plasma: a multiomic analysis
Extracellular Vesicles (EVs) derived from seminal plasma have achieved considerable attention due to their potential role in male reproductive physiology and pathology. In this study, we employed a comprehensive proteomic and transcriptomic approach to investigate the molecular signatures of EVs iso...
ORGANISM(S): Homo sapiens (Human) 
2025-06-30 | PXD051361 | Pride
Extracellular vesicles  seminal plasma  multi-omics  proteomics  transcriptomics 
ProteomicsDepletion of the RNA binding protein HNRNPD impairs homologous recombination by inhibiting DNA-end resection and inducing R-loop accumulation
DNA double strand break (DSB) repair through homologous recombination (HR) is crucial to maintain genome stability. DSB resection generates a single strand DNA intermediate, which is crucial for the HR process. We used a synthetic DNA structure, mimicking a resection intermediate, as a bait to ident...
ORGANISM(S): Homo sapiens (Human) 
2019-02-26 | PXD012045 | Pride
Rna binding proteins  hnrnpd  dna damage  dna end resection  rna binding proteins  r-loop 
ProteomicsCharacterization of extracellular vesicles in human seminal plasma: a multiomic analysis
Extracellular Vesicles (EVs) derived from seminal plasma have achieved considerable attention due to their potential role in male reproductive physiology and pathology. In this study, we employed a comprehensive proteomic and transcriptomic approach to investigate the molecular signatures of EVs iso...
ORGANISM(S): Homo sapiens (Human) 
2025-06-30 | PXD051390 | Pride
Extracellular vesicles  seminal plasma  multi-omics  proteomics  transcriptomics 
ProteomicsInvestigating the Cytoprotective Mechanisms of the Tardigrade Damage Suppressor (Dsup) Protein in Human Cells Under Hypoxic Stress
Introduction: Ischemia/reperfusion injury (IRI) is a common damage due to the restoration of blood flow after an ischemic insult. The pathogenesis of IRI is mainly linked to the production of ROS which sustain cell damage and ultimately promote cell death. The tardigrade damage suppressor protein (D...
ORGANISM(S): Homo sapiens (Human) 
2025-11-24 | PXD067125 | Pride
Ischemia Autophagy Reperfusion Dsup Oxidative stress Proteomic 
ProteomicsCockayne syndrome group A and ferrochelatase finely tune ribosomal gene transcription and its response to UV irradiation
CSA and CSB proteins are key players in transcription-coupled nucleotide excision repair (TC-NER) pathway that removes UV-induced DNA lesions from the transcribed strands of expressed genes. Additionally, CS proteins play relevant but still elusive roles in other cellular pathways whose alteration m...
ORGANISM(S): Homo sapiens (Human) 
2021-10-11 | PXD023472 | Pride
Fech Nucleolus Cs proteins Uv-induced dna damage Rnap1 transcription 
ProteomicsProteostasis network alteration in lysosomal storage disorders: insights from the mouse model of Krabbe diseaseProteostasis network alteration in lysosomal storage disorders: insights from the mouse model of Krabbe diseaseProteostasis network alteration in lysosomal storage disorders: insights from the mouse model of Krabbe disease
Krabbe disease is characterized by widespread demyelination due to cell death by apoptosis, mainly in oligodendrocytes and Schwann cells. In this study, we highlight that in the brain of 6 days old twitcher mice (model of Krabbe disease) there is evidence of impairment in protein synthesis and degra...
ORGANISM(S): Mus musculus (Mouse) 
2019-12-09 | PXD015320 | Pride
Cytoskeleton remodelling Lamin meshwork disaggregation Krabbe disease Twitcher Er stress 
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