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TranscriptomicsCRISPR enhancer scan to detect critical elements for the regulation of EVI1 in a translocated enhancer
To uncover, in an unbiased fashion, which elements of the 18 kb translocated region control EVI1 transcription, we devised a CRISPR/Cas9-based enhancer scanning approach. We considered all possible sgRNA target sites containing a canonical Cas9 PAM site (NGG) on both strands of the minimal 18 kb tra...
ORGANISM(S): Homo sapiens 
2021-07-26 | E-MTAB-9948 | biostudies-arrayexpress
UnknownExistence of distinct tyrosylprotein sulfotransferase genes: molecular characterization of tyrosylprotein sulfotransferase-2.
Not available
S-EPMC21608 | biostudies-literature
ProteomicsTargeting ERAP enhances anti-tumor immunity by disrupting the NKG2A/HLA-E inhibitory checkpoint
Tsao H, Anderson S, Finn KJ, Perera J, Pass LF, Schneider EM, Jiang A, Fetterman R, Chuong CL, Kozuma K, Stickler MM, Creixell M, Klaeger S, Phulphagar KM, Rachimi S, Verzani EK, Olsson N, Dubrot J, Pech MF, Silkworth W, Lane-Reticker SK, Allen PM, Ibrahim K, Knudsen NH, Cheng AY, Long AH, Ebrahimi-...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2024-05-10 | MSV000094736 | MassIVE
TranscriptomicsMYC activation and BCL2L11 silencing by a tumor virus through the large-scale reconfiguration of enhancer-promoter hubs [Bcell]
Lymphomagenesis in the presence of deregulated MYC expression requires suppression of MYC-driven apoptosis, often through downregulation of the pro-apoptotic BCL2L11 gene (Bim). Transcription factors (EBNAs) encoded by the lymphoma-associated Epstein-Barr virus (EBV) activate MYC and silence BCL2L11...
ORGANISM(S): Homo sapiens 
2016-08-04 | E-GEOD-82148 | biostudies-arrayexpress
UnknownToward a fluorescent single-strand conformation polymorphism technique that detects all mutations: F-DOVAM-S.
Not available
S-EPMC2729706 | biostudies-literature
GenomicsCistrome of the Aldosterone-activated Mineralocorticoid Receptor in Human Renal Cells
Aldosterone, the main mineralocorticoid hormone in Humans, has a major role in maintaining the hemo-electrolytique homeostasis, by acting in the distal part of nephron. This steroid hormone mainly acts through its binding to a ligand-induced transcription factor, the mineralocorticoid receptor (MR)....
ORGANISM(S): Homo sapiens 
2015-06-12 | E-GEOD-69777 | biostudies-arrayexpress
UnknownAssociation of remote mild traumatic brain injury with cortical amyloid burden in clinically normal older adults.
Not available
S-EPMC8272743 | biostudies-literature
TranscriptomicsTranscriptome of rice seedling and callus based on RNA-seq method
To support our research of epigenomics in rice genome, we conducted massively parallel pyrosequencing of mRNAs (RNA-seq) using rice seedling and callus tissues. We obtained a total of 40.1 M reads from seedling and 29.6 M reads from callus.The RNA-seq data derived from the replicates showed high cor...
ORGANISM(S): Oryza sativa Japonica Group 
2011-11-09 | E-GEOD-33265 | biostudies-arrayexpress
TranscriptomicsIntegrated microRNA and mRNA Signatures Associated with Survival in Triple Negative Breast Cancer
Triple negative breast cancer (TNBC) includes basal and non-basal subclasses. To further stratify TNBC we determined microRNA (miRNA) and mRNA expression profiles, linked specific miRNA signatures to patient survival and used miRNA/mRNA anti-correlations to identify TNBC subclasses associated with e...
ORGANISM(S): Homo sapiens 
2013-04-19 | E-GEOD-41970 | biostudies-arrayexpress
TranscriptomicsMicrobial RNAseq analysis of cecal and fecal samples collected from mice colonized with the microbiota of human twins discordant for obesity
Microbial RNAseq analysis of cecal and fecal samples collected from mice colonized with the microbiota of human twins discordant for obesity. Samples were colleted at the time of sacrifice, or 15 days after colonization from mice gavaged with uncultured or cultured fecal microbiota from the lean twi...
ORGANISM(S): mouse gut metagenome 
2013-10-01 | E-GEOD-48861 | biostudies-arrayexpress
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