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ProteomicsProteome-wide profiling of the selectivity of diverse electrophiles (part 2)
Targeted covalent inhibitors (TCIs) are established as powerful entities in drug discovery, but their application has so far mainly been limited to addressing cysteine. Competitive, residue-specific proteomics has been instrumental to streamline covalent drug discovery targeting cysteine. Several pr...
ORGANISM(S): Homo sapiens (Human) Staphylococcus aureus 
2025-08-04 | PXD065811 | Pride
Human Chemical proteomics S. aureus 
ProteomicsRab1b-AMPylation by Legionella DrrA is allosterically activated by Rab1
Legionella pneumophila infect eukaryotic cells by forming a replicative organelle – the Legionella containing vacuole. During this process, the bacterial protein DrrA/SidM is secreted and manipulates the activity and posttranslational modification (PTM) states of the vesicular trafficking regulator ...
ORGANISM(S): Legionella pneumophila Homo sapiens (Human) 
2021-01-04 | PXD019043 | Pride
Crosslink Legionella Rab Drra 
TranscriptomicsCHAC1 mRNA expression is a strong prognostic biomarker in breast and ovarian cancer
Extracellular, cancer-specific methylated DNA has been shown to be a prognostic marker when detected in serum or plasma. In this study we investigated the effect of treating cancer cells with differentially methylated CpG DNA. When breast cancer cell lines were treated with methylated CpG DNA, a con...
ORGANISM(S): Homo sapiens 
2011-12-01 | E-GEOD-22865 | biostudies-arrayexpress
ProteomicsSubstrate profiling of mitochondrial caseinolytic protease P via a site-specific photocrosslinking approach
The function of proteases is mainly determined by the substrates they are processing. However, substrate identification remains a challenging task. Here, we used genetic code expansion to incorporate a diazirine-lysine amino acid (DiazK) at selected positions of mitochondrial caseinolytic protease P...
ORGANISM(S): Homo sapiens (Human) 
2023-08-22 | PXD027954 | Pride
Mtupr Mitochondria Photoaffinity crosslinking Clpxp Orbitrap fusion 
UnknownBasal cell carcinoma risk and solar UV exposure in occupationally relevant anatomic sites: do histological subtype, tumor localization and Fitzpatrick phototype play a role? A population-based case-control study.
Not available
S-EPMC7488106 | biostudies-literature
UnknownEffect of Dapagliflozin in DAPA-HF According to Background Glucose-Lowering Therapy.
Not available
S-EPMC7809714 | biostudies-literature
UnknownExtrapolating Long-term Event-Free and Overall Survival With Dapagliflozin in Patients With Heart Failure and Reduced Ejection Fraction: An Exploratory Analysis of a Phase 3 Randomized Clinical Trial.
Not available
S-EPMC8576587 | biostudies-literature
UnknownGlobal maps of soil temperature.
Not available
S-EPMC9303923 | biostudies-literature
UnknownInterleukin-2 therapy in patients with HIV infection.
Not available
S-EPMC2869083 | biostudies-literature
UnknownSeverity of cardiovascular disease outcomes among patients with HIV is related to markers of inflammation and coagulation.
Not available
S-EPMC4309077 | biostudies-literature
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