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TranscriptomicsTranscriptome analysis of JAK2wt and JAK2V617F+ iPSCs and iPSC-derived CD34+ progenitor-enriched cultures, either inflammatory cytokines treated or untreated.
PV-patient specific and control healthy individual-derived iPSCs were upon differentiation for 9 days into CD34+ hematopoietic progenitors treated with IFNγ, TNFα and TGFβ1 or untreated and used for transcriptome analysis. This dataset shows presence of cell-autonomous and strong non-cell autonomous...
ORGANISM(S): Homo sapiens 
2020-12-03 | E-MTAB-7693 | biostudies-arrayexpress
UnknownNovel homozygous VHL mutation in exon 2 is associated with congenital polycythemia but not with cancer.
Not available
S-EPMC3976221 | biostudies-literature
UnknownSpecific phosphorylation of microtubule-associated protein 2c by extracellular signal-regulated kinase reduces interactions at its Pro-rich regions.
Not available
S-EPMC9520037 | biostudies-literature
Unknownβ-Thalassemia due to intronic LINE-1 insertion in the β-globin gene (HBB): molecular mechanisms underlying reduced transcript levels of the β-globin(L1) allele.
Not available
S-EPMC4993193 | biostudies-literature
UnknownOxidative DNA Damage, Inflammatory Signature, and Altered Erythrocytes Properties in Diamond-Blackfan Anemia.
Not available
S-EPMC7768356 | biostudies-literature
UnknownWnt Effector TCF4 Is Dispensable for Wnt Signaling in Human Cancer Cells.
Not available
S-EPMC6162433 | biostudies-literature
UnknownHIC1 Expression Distinguishes Intestinal Carcinomas Sensitive to Chemotherapy.
Not available
S-EPMC4833890 | biostudies-literature
TranscriptomicsExpression profiling of platelets from young (3 months) homozygous Jak2 R1063H mice and wild-type controls
Patients with myeloproliferative neoplasms (MPN), are known to be at an elevated risk for thrombosis but the mechanism for MPN-related coagulation activation is not yet fully characterized. While increased hematocrit has been re-evaluated as a contributing factor, additional mechanisms such as chron...
ORGANISM(S): Mus musculus 
2025-08-22 | E-MTAB-14685 | biostudies-arrayexpress
UnknownAlternatively spliced NFKB1 transcripts enriched in Andean Aymara modulate inflammation, HIF and hemoglobin.
Not available
S-EPMC11840074 | biostudies-literature
UnknownStructural basis of binding the unique N-terminal domain of microtubule-associated protein 2c to proteins regulating kinases of signaling pathways.
Not available
S-EPMC11367651 | biostudies-literature
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