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TranscriptomicsFibrotic Myofibroblasts Manifest Genome-Wide Derangements of Translational Control
As a group, fibroproliferative disorders of the lung, liver, kidney, heart, vasculature and integument are common, progressive and refractory to therapy. They can emerge following toxic insults, but are frequently idiopathic. Their enigmatic propensity to resist therapy and progress to organ failure...
ORGANISM(S): Homo sapiens 
2008-11-20 | E-GEOD-11196 | biostudies-arrayexpress
TranscriptomicseIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression
Translational regulation plays a critical role in cell growth and proliferation, and its dysregulation results in cancer. Aberrant expression of the mRNA 5’cap-binding protein, eIF4E, has been implicated in cancer development and progression. eIF4E activity is promoted by phosphorylation. Here we sh...
ORGANISM(S): Mus musculus 
2010-08-17 | E-GEOD-17451 | biostudies-arrayexpress
TranscriptomicsDistinct translational control in CD4+ T-cell subsets
Regulatory T cells expressing the transcription factor Foxp3 play indispensable roles for the induction and maintenance of immunological self-tolerance and immune homeostasis. Genome-wide mRNA expression-studies have defined canonical signatures of T-cell subsets. Changes in steady-state mRNA levels...
ORGANISM(S): Mus musculus 
2013-06-01 | E-GEOD-45401 | biostudies-arrayexpress
TranscriptomicsTumor Cell Survival Dependence on the DExH-Box Helicase DHX9
The ATP-dependent DExH/D-box helicase DHX9 is a key participant in a number of gene regulatory steps, including transcriptional, translational, microRNA-mediated control, DNA replication, and maintenance of genomic stability. DHX9 has also been implicated in maintenance of the tumorigenic process an...
ORGANISM(S): Mus musculus 
2016-05-19 | E-GEOD-76765 | biostudies-arrayexpress
TranscriptomicsEpigenetic activation of a subset of mRNAs identified using polyribosome microarray analysis
Background: Translation deregulation is an important mechanism that causes aberrant cell growth, proliferation and survival. eIF4E, the mRNA 5 prime capâ??binding protein, plays a major role in translational control. To understand how eIF4E affects cellular proliferation and cell survival, we identi...
ORGANISM(S): Mus musculus 
2010-06-11 | E-GEOD-6639 | biostudies-arrayexpress
TranscriptomicsTranslational control of cell viability downstreams of eIF4E, using polyribosome RNA
Aberrant activation of the translation initiation machinery is a common property of malignant cells, and is essential for breast carcinoma cells to manifest a malignant phenotype. How does sustained activation of the rate limiting step in protein synthesis so fundamentally alter a cell? In this repo...
ORGANISM(S): Mus musculus 
2010-06-10 | E-GEOD-2094 | biostudies-arrayexpress
TranscriptomicsDose-dependent dual roles of PDGF-BB–PDGFR-? in vascular remodeling and opposing effects of anti-PDGF drug-induced metastasis
Anti-PDGF agents are routinely used as a key component in front-line therapy for the treatment of various cancers. However, molecular mechanisms underlying their impact on vascular remodeling in relation to the dose issue remain poorly understood. Here we show that in high PDGF-BB-producing tumors, ...
ORGANISM(S): Mus musculus 
2013-07-22 | E-GEOD-46564 | biostudies-arrayexpress
MetabolomicsMass spectrometry based metabolomics for in vitro systems pharmacology: Pitfalls, challenges, and computational solutions

INTRODUCTION: Mass spectrometry based metabolomics has become a promising complement and alternative to transcriptomics and proteomics in many fields including in vitro systems pharmacology. Despite several merits, metabolomics based on liquid chromatography mass spectrometry (LC...

2017-08-23 | MTBLS401 | MetaboLights
TranscriptomicsnanoCAGE reveals 5’ UTR features that define specific modes of translation of functionally related mTOR-sensitive mRNAs
mTOR regulates mRNA translation. Whereas ribosome-profiling suggested that mTOR exclusively stimulates translation of TOP (containing a 5’-terminal oligopyrimidine [5’TOP] motif) and TOP-like mRNAs, polysome-profiling implied that mTOR also modulates translation of non-TOP mRNAs. We show that ri...
ORGANISM(S): Homo sapiens 
2016-03-14 | E-GEOD-77033 | biostudies-arrayexpress
MetabolomicsIntegration of magnetic resonance imaging and protein and metabolite CSF measurements to enable early diagnosis of secondary progressive multiple sclerosis

Molecular networks in neurological diseases are complex. Despite this fact, contemporary biomarkers are in most cases interpreted in isolation, leading to a significant loss of information and power. We present an analytical approach to scrutinize and combine information from biomarkers originati...

2018-08-13 | MTBLS558 | MetaboLights
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