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MetabolomicsELAPOR1 induces the classical/progenitor subtype and contributes to reduced disease aggressiveness through metabolic reprogramming in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is a heterogeneous disease with distinct molecular subtypes described as classical/progenitor and basal-like/squamous PDAC. We hypothesized that integrative transcriptome and metabolome approaches can identify candidate genes whose inactivation contributes to ...
2024-04-02 | MTBLS9418 | MetaboLights
ProteomicsIdentification of human GRHL1 interactors and post-translational modifications by LC-MS/MS
Aim of the project was to identify interactors and post-translational modifications of recombinant 3xFLAG-6xHis-tagged human GRHL1, tandem-affinity purified from isolated HEK293 nuclei treated with DMSO as control or with the phytochemical papaverine.
ORGANISM(S): Homo sapiens (Human) 
2021-11-02 | PXD021768 | Pride
Interactors Transcription factor Post-translational modification Grhl1 Lc-ms/ms 
ProteomicsMouse Liver LC-MS/MS Analysis Following Treatment With Lifespan-Extending Drugs
Aging manifests as progressive deterioration in cellular and systemic homeostasis, requiring systems-level perspectives to understand the gradual molecular dysregulation of underlying biological processes. Here, we collected data for the analysis of systems-level changes in the molecular regulation ...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-25 | PXD035255 | Pride
Mouse Shotgun ms/ms Liver Orbitrap Lifespan 
ProteomicsDnj4HA AP-MS in Cryptococcus neoformans
Proteins which act as histone chaperones ensure genomic integrity during routine processes such as DNA replication and transcription as well as DNA repair upon damage. Herein, we identify a nuclear J domain protein, Dnj4, which interacts with histones 3 and 4 as well as Hsp71 as demonstrated in an A...
ORGANISM(S): Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii) 
2021-12-15 | PXD028087 | Pride
Histone Co-chaperone Cryptococcus neoformans J domain protein 
TranscriptomicsHippocampal expression data from FTY720- and vehicle-treated SCID mice following fear consolidation testing
FTY720/Fingolimod, an FDA-approved drug for treatment of multiple sclerosis, has beneficial effects in the CNS that are not yet well understood, independent of its effects on immune cell trafficking. Here we show that FTY720 enters the nucleus where it is phosphorylated by sphingosine kinase 2 (SphK...
ORGANISM(S): Mus musculus 
2014-05-12 | E-GEOD-57015 | biostudies-arrayexpress
Metabolomics3D'omics: Salmonella challenge chicken trial

BioProject PRJEB86258 at https://www.ebi.ac.uk/ena/browser/view/PRJEB86258


The full study description is published in detail before:

Poult Sci. 2025 Feb 6;104(4):104890. doi: 10.1016/j.psj.2025.104890

“Differential effects of synbiotic delivery route (Feed, water, com...

2025-11-19 | MTBLS13315 | MetaboLights
GenomicsGenome-wide analysis of acetylated H4K5 binding offers new insights into the acute and chronic effects of METH on gene expression in the dorsal striatum
In contrast to the acute METH-induced transcriptional changes, chronic METH administration produces differential changes in IEG responses and blunts the striatal effects of a single METH injection (McCoy et al., 2011). These observations suggested that chromic METH might have caused changes in the m...
ORGANISM(S): Rattus norvegicus 
2013-02-28 | E-GEOD-42776 | biostudies-arrayexpress
ProteomicsMrj1HA AP-MS in Cryptococcus neoformans
The opportunistic fungal pathogen Cryptococcus neoformans must adapt to the mammalian environment to establish an infection. Proteins facilitating adaptation to novel environments, such as chaperones, may be required for virulence. In this study, we identified a novel mitochondrial co-chaperone, Mrj...
ORGANISM(S): Cryptococcus neoformans var. grubii H99S 
2020-06-12 | PXD013659 | Pride
Cryptococcus neoformans 
UnknownGenomic insights into the diversity, virulence and resistance of Klebsiella pneumoniae extensively drug resistant clinical isolates.
Not available
S-EPMC8549359 | biostudies-literature
MetabolomicsMetabolic characterization of directly reprogrammed renal tubular epithelial cells (iRECs)
Fibroblasts can be directly reprogrammed to induced renal tubular epithelial cells (iRECs) using four transcription factors. These engineered cells may be used for disease modeling, cell replacement therapy or drug and toxicity testing. Direct reprogramming induces drastic changes in the transcripti...
2021-08-20 | MTBLS608 | MetaboLights
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