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TranscriptomicsPolygenic and directional regulatory evolution across pathways in Saccharomyces
We assess the prevalence of polygenic evolution in pathways between the yeasts S. cerevisiae and S. bayanus. We first established short-read sequencing methods to detect cis-regulatory variation in a diploid hybrid between the species. We then formulated an analytic strategy to test for the scenar...
ORGANISM(S): Saccharomyces bayanus x Saccharomyces cerevisiae 
2010-02-22 | E-GEOD-19837 | biostudies-arrayexpress
ProteomicsMetabolic bypass partially rescues S-nitrosylation-induced TCA cycle inhibition and synapse loss in Alzheimer’s disease human neurons
In Alzheimer’s disease (AD), dysfunctional mitochondrial metabolism has been associated with synaptic loss, the major pathological correlate of cognitive decline. Mechanistic insight for this relationship, however, is still lacking. Here, comparing isogenic wild-type and AD mutant human induced plur...
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD042436 | Pride
S-nitrosylation Alzheimer’s disease Mitochondrial metabolism Tca cycle inhibition 
TranscriptomicsPhenotype and expression profile of S. erythraea rifampicin-resistant (rif) mutants affected in erythromycin production
In this study we have used the rifampicin selection as a tool to genetically improve the erythromycin producer Saccharopolyspora erythraea. Two rifampicin-resistant (rif) mutants, rif1 and rif6, have been characterized in more detail. With respect to the parental strain NRRL2338, rif1 (harboring the...
ORGANISM(S): Saccharopolyspora erythraea 
2009-04-12 | E-GEOD-12017 | biostudies-arrayexpress
GenomicsWGS S. aureus Dupilomab
WGS S. aureus analysis of AD patients treated with dupilumab
PRJEB81872 | ENA
UnknownSynthesis of aryl-substituted thieno[3,2-b]thiophene derivatives and their use for N,S-heterotetracene construction.
Not available
S-EPMC6880844 | biostudies-literature
TranscriptomicsBES performance of S. oneidensis pure- and co-culture
Bioelectrochemical systems employing mixed microbial communities as biocatalysts are gaining importance as potential renewable energy, bioremediation, or biosensing devices. While we are beginning to understand how individual microorganism species interact with an electrode as electron donor, not mu...
ORGANISM(S): Shewanella oneidensis MR-1 
2010-12-01 | E-GEOD-20343 | biostudies-arrayexpress
TranscriptomicsA general framework for optimization of probes for gene expression microarray and its application to the fungus Podospora anserina
A genome wide microarray, covering the 10546 presently known and predicted CDS, has been constructed with the Agilent in-situ synthesized 60-mers technology. 1) A library of 10 oligonucleotides per CDS has been design by the manufacturer. 2) A computational step has been performed to determine 3' po...
ORGANISM(S): Podospora anserina 
2010-06-30 | E-GEOD-20734 | biostudies-arrayexpress
TranscriptomicsOverproduction of indole-3-acetic acid in free-living rhizobia mimics physiological conditions required for nitrogen fixation inside root nodules
Background: The overproduction of the main auxin indole-3-acetic acid (IAA) in Sinorhizobium meliloti RD64 leads to beneficial effects both in free-living rhizobium and in host plant during symbiosis. These effects could be related to alteration in gene expression induced by IAA. Preliminary studies...
ORGANISM(S): Sinorhizobium meliloti 
2016-03-30 | E-GEOD-69880 | biostudies-arrayexpress
TranscriptomicsGlobal analysis of the Staphylococcus aureus response to mupirocin
In the present study we analyzed the response of S. aureus to mupirocin, the drug of choice for nasal decolonization of S. aureus. Mupirocin selectively inhibits the bacterial isoleucyl-tRNA synthetase (IleRSs) leading to the accumulation of uncharged isoleucyl-tRNA and hence (p)ppGpp. The latter is...
ORGANISM(S): Staphylococcus aureus 
2012-01-23 | E-GEOD-30743 | biostudies-arrayexpress
UnknownEnantioselective induction of a glutathione-S-transferase, a glutathione transporter and an ABC transporter in maize by Metolachlor and its (S)-isomer.
Not available
S-EPMC3483294 | biostudies-literature
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