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TranscriptomicsAn Extended dsRBD with a Novel Zinc-Binding Motif Mediates Nuclear Retention of Fission Yeast Dicer
Dicer proteins function in RNA interference (RNAi) pathways by generating small RNAs (sRNAs). Here we report the solution structure of the C-terminal domain of Schizosaccharomyces pombe Dicer (Dcr1). The structure reveals an unusual double-stranded RNA binding domain (dsRBD) fold embedding a novel z...
ORGANISM(S): Schizosaccharomyces pombe 
2011-09-22 | E-GEOD-30549 | biostudies-arrayexpress
TranscriptomicsNuclear retention of fission yeast dicer is a prerequisite for RNAi-mediated heterochromatin assembly
RNAseIII ribonucleases act at the heart of RNA silencing pathways by processing precursor RNAs into mature microRNAs and siRNAs. In the fission yeast Schizosaccharomyces pombe, siRNAs are generated by the RNAseIII enzyme Dcr1 and are required for heterochromatin formation. In this study, we have ana...
ORGANISM(S): Schizosaccharomyces pombe 
2010-02-16 | E-GEOD-18582 | biostudies-arrayexpress
TranscriptomicsAn Integrated Model of the Transcriptome Landscape of HER2-Positive Breast Cancer
The goal of our study is to build an integrated transcriptome landscape model for HER2 positive breast tumors and identify the crucial signaling pathways associated with HER2 tumors. Genomic features include, 685 genes that were differentially expressed only in HER2-positive tumors, 102 genes that w...
ORGANISM(S): Homo sapiens 
2013-12-06 | E-GEOD-45419 | biostudies-arrayexpress
UnknownXenotransplantation of pediatric low grade gliomas confirms the enrichment of BRAF V600E mutation and preservation of CDKN2A deletion in a novel orthotopic xenograft mouse model of progressive pleomorphic xanthoastrocytoma.
Not available
S-EPMC5675646 | biostudies-literature
UnknownOutcomes of influenza A(H1N1)pdm09 virus infection: results from two international cohort studies.
Not available
S-EPMC4086938 | biostudies-literature
UnknownComparison of the Outcomes of Individuals With Medically Attended Influenza A and B Virus Infections Enrolled in 2 International Cohort Studies Over a 6-Year Period: 2009-2015.
Not available
S-EPMC5740982 | biostudies-literature
UnknownInitiation of Antiretroviral Therapy in Early Asymptomatic HIV Infection.
Not available
S-EPMC4569751 | biostudies-literature
UnknownWhy START? Reflections that led to the conduct of this large long-term strategic HIV trial.
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S-EPMC4347998 | biostudies-literature
UnknownInterleukin-2 therapy in patients with HIV infection.
Not available
S-EPMC2869083 | biostudies-literature
UnknownSeverity of cardiovascular disease outcomes among patients with HIV is related to markers of inflammation and coagulation.
Not available
S-EPMC4309077 | biostudies-literature
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