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ProteomicsSynaptic Signatures and Disease Vulnerabilities of Layer 5 Pyramidal Neurons - second data set
Cortical layer 5 (L5) intratelencephalic (IT) and pyramidal tract (PT) neurons are embedded in distinct information processing pathways. The morphology, connectivity, electrophysiological properties, and role in behavior of these neurons have been extensively analyzed. However, the molecular composi...
ORGANISM(S): Mus musculus (Mouse) 
2024-11-04 | PXD052081 | Pride
Neurons Synapses 
GenomicsAnalysis of microisolated frontal cortex excitatory layer III and V pyramidal neurons reveals a neurodegenerative phenotype in individuals with Down syndrome
Analysis of microisolated frontal cortex excitatory layer III and V pyramidal neurons reveals a neurodegenerative phenotype in individuals with Down syndrome
PRJNA1055954 | ENA
TranscriptomicsTbr1 regulates regional and laminar identity of postmitotic neurons in developing neocortex
Areas and layers of the cerebral cortex are specified by genetic programs that are initiated in progenitor cells and then, implemented in postmitotic neurons. Here, we report that Tbr1, a transcription factor expressed in postmitotic projection neurons, exerts positive and negative control over both...
ORGANISM(S): Mus musculus 
2010-07-27 | E-GEOD-22371 | biostudies-arrayexpress
UnknownAberrant excitatory rewiring of layer V pyramidal neurons early after neocortical trauma.
Not available
S-EPMC4860078 | biostudies-literature
UnknownCannabidiol reduces synaptic strength and neuronal firing in layer V pyramidal neurons of the human cortex with drug-resistant epilepsy.
Not available
S-EPMC12321821 | biostudies-literature
TranscriptomicsTranscription profiling of mouse hippocampus after maternal treatment with saline or 20 mg/kg cocaine twice daily on gestational days 8-19
We explored the hypothesis that maternal cocaine exposure could alter the fetal epigenetic machinery sufficiently to cause lasting neurochemical and functional changes in the offspring. These data were used as preliminary results for paper:; Maternal cocaine administration in mice alters DNA methy...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-6651 | biostudies-arrayexpress
UnknownExcitatory and inhibitory effects of HCN channel modulation on excitability of layer V pyramidal cells.
Not available
S-EPMC9506642 | biostudies-literature
UnknownPrenatal Exposure to Ethanol Alters Synaptic Activity in Layer V/VI Pyramidal Neurons of the Somatosensory Cortex.
Not available
S-EPMC7132917 | biostudies-literature
UnknownDistribution and properties of functional postsynaptic kainate receptors on neocortical layer V pyramidal neurons.
Not available
S-EPMC6740632 | biostudies-literature
UnknownDown syndrome frontal cortex layer III and layer V pyramidal neurons exhibit lamina specific degeneration in aged individuals.
Not available
S-EPMC11603868 | biostudies-literature
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