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GenomicsMALDI imaging and LC-MS/MS-based fast, high-resolution spatial proteomics demonstrate cellular heterogeneity in situ
MALDI imaging and LC-MS/MS-based fast, high-resolution spatial proteomics demonstrate cellular heterogeneity in situ
PRJNA1014120 | ENA
ProteomicsEnhancement of Tryptic Peptide Signals from Tissue Sections using MALDI IMS Post-ionization (MALDI-2)
Matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS) allows for highly multiplexed, unlabeled mapping of analytes from tissue sections. However, further work is needed to improve sensitivity and depth of coverage for protein and peptide IMS. Laser-based post-ionization ...
ORGANISM(S): Homo sapiens (Human) 
2021-12-30 | PXD023877 | Pride
Kidney Imaging mass spectrometry Maldi-2 Lc-ms/ms 
OtherMALDI imaging and LC-MS/MS-based fast, high-resolution spatial proteomics demonstrate cellular heterogeneity in situ
Highly specialized cells are fundamental for proper functioning of complex organs. Variations in cell-type specific gene expression and protein composition have been linked to a variety of diseases. Although single cell technologies have emerged as valuable tools to address this cellular heterogenei...
ORGANISM(S): Mus musculus 
2024-07-24 | GSE242688 | GEO
ProteomicsIdentification of proteomic markers in head and neck cancer using MALDI-MS Imaging, LC-MS/MS and IHC
Purpose The heterogeneity of squamous cell carcinoma tissue complicates diagnosis and an individualized therapy to a great extent. Therefore it is of utmost importance to spatially characterize this tissue heterogeneity and to identify appropriate biomarkers. Matrix assisted laser desorption/ionizat...
ORGANISM(S): Homo sapiens (Human) 
2018-11-14 | PXD009144 | Pride
Cancer Maldi-ms imaging Immunohistochemistry Biomarker Lc-ms/ms 
UnknownMicrofluidic LC device with orthogonal sample extraction for on-chip MALDI-MS detection.
Not available
S-EPMC4123744 | biostudies-literature
ProteomicsGrass carp serum IgM LC-ESI-MS/MS and MALDI-MS
Glycosylation represents a major post-translational modification of proteins that can influence their structure and function.Telesot immunoglobulin M (IgM) is an especially important product of the immune system because it is the main Abs in seum and plays a critical role against defense infection. ...
ORGANISM(S): Ctenopharyngodon idella 
2018-11-29 | PXD010308 | Pride
Lc-ms/ms) Grass carp Immunoglobulin m Maldi-ms 
UnknownPeptidome analysis of cerebrospinal fluid by LC-MALDI MS.
Not available
S-EPMC3412831 | biostudies-literature
ProteomicsMALDI imaging and LC-MS/MS-based fast, high-resolution spatial proteomics demonstrate cellular heterogeneity in situ
Highly specialized cells are fundamental for proper functioning of complex organs. Variations in cell-type specific gene expression and protein composition have been linked to a variety of diseases. Although single cell technologies have emerged as valuable tools to address this cellular heterogenei...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-17 | PXD044958 | Pride
Cellular heterogeneity Laser capture microdissection Imaging mass spectrometry Proteomics Data integration Dentate gyrus 
UnknownDetection and identification of a protein biomarker in antibiotic-resistant Escherichia coli using intact protein LC offline MALDI-MS and MS/MS.
Not available
S-EPMC7444928 | biostudies-literature
UnknownEnhanced In Situ Spatial Proteomics by Effective Combination of MALDI Imaging and LC-MS/MS.
Not available
S-EPMC11345593 | biostudies-literature
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