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MetabolomicsOptimised LC-MS Metabolomic Profiling Reveals Emergent Changes to Monocyte Metabolism in Response to Lipopolysaccharide
Immunometabolism examines the links between immune cell function and metabolism. Dysregulation of immune cell metabolism is now an established feature of innate immune cell activation. Advances in liquid chromatography mass spectrometry (LC-MS) technologies have allowed discovery of unique insights ...
2025-11-17 | MTBLS6730 | MetaboLights
MetabolomicsUntargeted LC-MS metabolomic profiling of Tulipa iliensis leaves during Botrytis tulipae infection
This study investigated the metabolic responses of Tulipa iliensis leaves to Botrytis tulipae infection using untargeted LC-MS metabolomics. Leaf tissues were collected at 0, 6, 12, 24, 48 and 72 h post-inoculation, with three biological replicates per time point. All samples were snap-frozen in liq...
2027-08-19 | MTBLS15393 | MetaboLights
MetabolomicsSerum LC-MS metabolomics profiling during musk secretion in captive forest musk deer (Moschus berezovskii)
This study investigates serum metabolomic changes associated with musk secretion in captive male forest musk deer (Moschus berezovskii). Paired serum samples were collected before secretion and during secretion and analyzed using LC-MS in both positive and negative ion modes. The study includes biol...
2026-04-23 | MTBLS14280 | MetaboLights
MetabolomicsDIA-based LC-MS proteomic profiling of serum from asthma patients with different TCM syndromes
Serum samples were collected from healthy controls and asthma patients classified into lung qi deficiency and phlegm turbidity obstructing lung syndromes. DIA LC-MS was performed to acquire proteomic data, differential proteins and related molecular pathways were analyzed to explore serum molecular ...
2026-09-02 | MTBLS14938 | MetaboLights
MetabolomicsMetabolic Drug Response Phenotyping in Colorectal Cancer Organoids by LC-QTOF-MS
As metabolic rewiring is crucial for cancer cell proliferation, metabolic phenotyping of patient-derived organoids is desirable to identify drug-induced changes and trace metabolic vulnerabilities of tumor subtypes. We established a novel protocol for metabolomic and lipidomic profiling of colorecta...
2021-10-12 | MTBLS2130 | MetaboLights
MetabolomicsUntargeted Metabolite Profiling (LC-MS) of Root Exudates of Grassland Species

Plants exude a diverse cocktail of metabolites into the soil as response to exogenous and endogenous influences. So far, root exudates have only been studied under artificial conditions due to methodological difficulties. In this study, each five perennial grass and forb species were investigated...

2020-06-18 | MTBLS865 | MetaboLights
MetabolomicsUntargeted LC-MS metabolomics profiling of mouse serum following I.v treatment compared with PBS controls
This study investigated serum metabolic alterations associated with I.v treatment in mice. Serum samples from I.v-treated mice and PBS-treated controls were analyzed by untargeted LC-MS metabolomics in both positive and negative ionization modes. The deposited dataset contains mzXML spectral data fr...
2026-09-30 | MTBLS15361 | MetaboLights
MetabolomicsDeep insights into microsampling technologies for global lipidomic profiling of human whole blood using high-throughput LC-MS

In recent years, blood microsampling (BμS) technologies have gained popularity, as they offer simplicity, minimal invasiveness, and suitability for remote sample collection. In this study, the aim was to explore the potential of three BμS devices for reliable untargeted lipidomic profiling using ...

2025-09-30 | MTBLS10722 | MetaboLights
MetabolomicsSteady state isotope tracing in C. elegans (LC-MS analyses)

The metabolic network, composed of thousands of metabolic reactions, is essential for any organism. Despite its importance, a systems level understanding of how metabolic network is wired by reactions that carry flux in unperturbed condition and rewired by transcriptionally activating or repressi...

2024-12-03 | MTBLS11741 | MetaboLights
MetabolomicsHuman age-declined saliva metabolic markers determined by LC-MS

Metabolites in human biofluids reflect individual physiological body states influenced by various factors. Using liquid chromatography-mass spectrometry (LC-MS), we conducted non-targeted, non-invasive, comprehensive metabolomics using saliva of 27 healthy volunteers in Okinawa, consisting of 13 ...

2021-02-11 | MTBLS2108 | MetaboLights
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